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QuickView for Mephentermine (compound)


PubChem
Name: Mephentermine
PubChem Compound ID: 297936
Description: A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
Molecular formula: C11H19NO4S
Molecular weight: 261.339 g/mol
Synonyms:
Mephentermine; NSC169447
DrugBank
Identification
Name: Mephentermine
Name (isomeric): DB01365
Drug Type: small molecule
Description: A sympathomimetic agent with specificity for alpha-1 adrenergic receptors. It is used to maintain BLOOD PRESSURE in hypotensive states such as following SPINAL ANESTHESIA.
Synonyms:
Mephenterdrinum; Mefenterdrin; N-methylphentermine; Mefentermin; Mephenterdrine; Mephetedrine
Brand: Wyamine, Wyfentermina, Vialin, Mephine
Category: Adrenergic alpha-Agonists, Adrenergic Agents, Sympathomimetics, Vasoconstrictor Agents
CAS number: 100-92-5
Pharmacology
Indication: Used to maintain blood pressure in hypotensive states.
Pharmacology:
Mephentermine is a sympathomimetic agent with mainly indirect effects on adrenergic receptors. It is used to maintain blood pressure in hypotensive states, for example, following spinal anesthesia. Although the central stimulant effects of mephentermine are much less than those of amphetamine, its use may lead to amphetamine-type dependence. (From ...
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Mechanism of Action:
Mephentermine is an alpha adrenergic receptor agonist, but also acts indirectly by releasing endogenous norepinephrine. Cardiac output and systolic and diastolic pressures are usually increased. A change in heart rate is variable, depending on the degree of vagal tone. Sometimes the net vascular effect may be vasodilation. Large doses may depress t...
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Biotransformation: Hepatic, by N-demethylation and then p-hydroxylation.
Half Life: 17 to 18 hours.
Affected organisms: Humans and other mammals
Interactions
Drug interaction:
TrimipramineTrimipramine may increase the vasopressor effect of the alpha1-agonist, Mephentermine. Avoid combination if possible. Monitor sympathetic response to therapy if used concomitantly.
PhenelzineIncreased arterial pressure
ImipramineThe tricyclic antidepressant, imipramine, increases the sympathomimetic effect of mephentermine.
IsocarboxazidIncreased arterial pressure
AmoxapineThe tricyclic antidepressant, amoxapine, increases the sympathomimetic effect of mephentermine.
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Targets