Name: | Methicillin |
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PubChem Compound ID: | 10670288 |
Description: | One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. |
Molecular formula: | C23H18N4O3S |
Molecular weight: | 430.48 g/mol |
Name: | Methicillin |
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Name (isomeric): | DB01603 |
Drug Type: | small molecule |
Description: | One of the PENICILLINS which is resistant to PENICILLINASE but susceptible to a penicillin-binding protein. It is inactivated by gastric acid so administered by injection. |
Synonyms: |
Meticilina [inn-spanish]; Methycillin; Methicillinum; Meticilline [inn-french]; (2,6-Dimethoxyphenyl)penicillin; 6-(2,6-Dimethoxybenzamido)penicillanic acid; Meticillinum [inn-latin]
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Brand: | Metacillin, Dimocillin |
Category: | Anti-Bacterial Agents, Penicillins |
CAS number: | 61-32-5 |
Indication: | Used to treat infections caused by susceptible Gram-positive bacteria, particularly beta-lactamase-producing organisms such as <i>Staphylococcus aureus</i> that would otherwise be resistant to most penicillins. |
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Pharmacology: |
Meticillin (INN, BAN) or methicillin (USAN) is a narrow spectrum beta-lactam antibiotic of the penicillin class. It is no longer clinically used. Its role in therapy has been largely replaced by flucloxacillin and dicloxacillin, however the term methicillin-resistant Staphylococcus aureus (MRSA) continues to be used to describe Staphyloco...
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Mechanism of Action: |
Like other beta-lactam antibiotics, meticillin acts by inhibiting the synthesis of bacterial cell walls. It inhibits cross-linkage between the linear peptidoglycan polymer chains that make up a major component of the cell wall of Gram-positive bacteria. It does this by binding to and competitively inhibiting the transpeptidase enzyme used by bacter...
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Absorption: | Not absorbed following oral administration. |
Biotransformation: | Hepatic (20-40%). |
Half Life: | 25-60 minutes |
Affected organisms: | Enteric bacteria and other eubacteria |
Drug interaction: |
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