QuickView for Methocarbamol (compound)

Summary
General Info

PubChem

PubChem Compound 4107

Name:	Methocarbamol
PubChem Compound ID:	4107
Description:	A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
Molecular formula:	C₁₁H₁₅NO₅
Molecular weight:	241.241 g/mol
Synonyms:	Methocarbamol (JAN/USP); Metocarbamol [INN-Spanish]; KBio1_000434; Myolaxene; SPBio_002028; KBio2_006613; 1,2-Propanediol, 3-(o-methoxyphenoxy)-, 1-carbamate; 3967-43-9; Tresortil; 1, 2-Propanediol, 3- (2-methoxyphenoxy)-, 1-carbamate. show more » Methocarbamol (JAN/USP); Metocarbamol [INN-Spanish]; KBio1_000434; Myolaxene; SPBio_002028; KBio2_006613; 1,2-Propanediol, 3-(o-methoxyphenoxy)-, 1-carbamate; 3967-43-9; Tresortil; 1, 2-Propanediol, 3- (2-methoxyphenoxy)-, 1-carbamate; 532-03-6; Prestwick_614; BRN 1884446; Romethocarb; 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate; Etroflex; Carbamic acid, 2-hydroxy-3-(o-methoxyphenoxy)propyl ester; NSC170960; Robaxisol; KBioGR_000517; Methocarbamolum [INN-Latin]; Metofenina; MLS000028610; Delaxin; Parabaxin; EINECS 208-524-3; 1, 2-Propanediol, 3- (o-methoxyphenoxy)-, 1-carbamate; Spectrum4_000049; 2-Hydroxy-3-(o-methoxyphenoxy)propyl 1-carbamate; SPBio_001264; AHR 85; D00402; 3-(o-Methoxyphenoxy)-1,2-propanediol 1-carbamate; Miowas; KBio2_004045; Miorilas; Guiacol-gliceriletere monocarbammato; Robaxon; Guaiacol glyceryl ether carbamate; Metocarbamol; Prestwick1_000184; Relax; Prestwick0_000184; Methocal; Metocarbamolo [DCIT]; Reflexyn; Relestrid; Methocarbamol [BAN:INN:JAN]; Guaiphenesine carbamate; Lumirelax; Miolaxene; Methocarbamol; Perilax; Spectrum2_001272; Spectrum_000997; Neuraxin; Metofenia; DivK1c_000434; 3-(2-Methoxyphenoxy)-1-glyceryl carbamate; Robaxin (TN); Metocarbamolo; NSC 170960; SMR000058719; component of Robaxisal; 145308-03-8; Spectrum3_000496; Robaxisal; Robaxan; Glycerylguajacol-carbamat; Surquetil; KBio2_001477; HSDB 3122; Glycerylguaiacolate carbamate; 3-(o-Methoxyphenoxy)-2-hydroxypropyl carbamate; NINDS_000434; KBio3_001491; Robaxin; Robaxine; Avetil; Robinax; KBioSS_001477; 4-06-00-05577 (Beilstein Handbook Reference) show less «

DrugBank

Identification

Name:	Methocarbamol
Name (isomeric):	DB00423
Drug Type:	small molecule
Description:	A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
Brand:	Surquetil, Metocarbamol, Glycerylguaiacolate carbamate, Miorilas, Robaxin, AHR 85, Reflexyn, Metofenia, Perilax, Guaiphenesin carbamate, Glycerylguajacol-Carbamat, Miolaxene, Tresortil, Robinax, Robaxine, Neuraxin, Guaiphenesine carbamate, Lumirelax, Relestrid, Robaxon, Traumacut, Forbaxin, Miowas, Parabaxin, Metocarbamolo, Methocal, Robaxan, Avetil, Myolaxene, Romethocarb, Guaiacol glyceryl ether carbamate, Etroflex, Delaxin, Metofenina, Robamol
Brand name mixture:	Muscle and Back Pain Relief-8(Acetaminophen + Codeine Phosphate + Methocarbamol), Robaxacet(Methocarbamol + Acetaminophen), Muscle & Back Pain Relief Extra Strength(Acetylsalicylic acid + Methocarbamol), Muscle and Back Pain Relief with Asa(Acetylsalicylic acid + Methocarbamol), Methoxacet Extra Strength(Acetaminophen + Methocarbamol), Extra Str... show more » Muscle and Back Pain Relief-8(Acetaminophen + Codeine Phosphate + Methocarbamol), Robaxacet(Methocarbamol + Acetaminophen), Muscle & Back Pain Relief Extra Strength(Acetylsalicylic acid + Methocarbamol), Muscle and Back Pain Relief with Asa(Acetylsalicylic acid + Methocarbamol), Methoxacet Extra Strength(Acetaminophen + Methocarbamol), Extra Strength Muscle & Back Pain ASA(Acetylsalicylic acid + Methocarbamol), Muscle & Back Pain ASA(Acetylsalicylic acid + Methocarbamol), Muscle Relaxant and Analgesic(Acetylsalicylic acid + Methocarbamol), Muscle & Back Pain Relief Caplets(Acetaminophen + Methocarbamol) show less «
Category:	Muscle Relaxants, Central
CAS number:	532-03-6

Pharmacology

Indication:	For use as an adjunct to rest, physical therapy, and other measures for the relief of discomforts associated with acute, painful musculoskeletal conditions.
Pharmacology:	Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers... show more » Methocarbamol is a central muscle relaxant for skeletal muscles, used to treat spasms. It is structurally related to guaifenesin. Methocarbamol's exact mechanism of causing skeletal muscle relaxation is unknown. It is thought to work centrally, perhaps by general depressant effects. It has no direct relaxant effects on striated muscle, nerve fibers, or the motor endplate. It will not directly relax contracted skeletal muscles. The drug has a secondary sedative effect. show less «
Mechanism of Action:	The mechanism of action of methocarbamol in humans has not been established, but may be due to central nervous system depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
Absorption:	Rapid. Onset of action is about 30 minutes after oral administration.
Biotransformation:	Hepatic.
Route of elimination:	Small amounts of unchanged methocarbamol also are excreted in the urine.
Half Life:	1.14-1.24 hours
Clearance:	0.2 – 0.8 L/h/kg [healthy]
Toxicity:	Symptoms of overdose include blurred vision, coma, drowsiness, low blood pressure, nausea, and seizures.
Affected organisms:	Humans and other mammals

Interactions

Food interaction:

Avoid alcohol.

Take without regard to meals.

Drug interaction:

Triprolidine

The CNS depressants, Triprolidine and Methocarbamol, may increase adverse/toxic effects due to additivity. Monitor for increased CNS depressant effects during concomitant therapy.

Targets

Carbonic anhydrase 1