Name: | Mephobarbital |
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PubChem Compound ID: | 6451435 |
Description: | A barbiturate that is metabolized to PHENOBARBITAL. It has been used for similar purposes, especially in EPILEPSY, but there is no evidence mephobarbital offers any advantage over PHENOBARBITAL. |
Molecular formula: | C13H14N2O3 |
Molecular weight: | 246.262 g/mol |
Synonyms: |
2671-99-0; (S)-5-Ethyl-1-methyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-ethyl-1-methyl-5-phenyl-, (S)-; (+)-Mephobarbitol; ZINC03831033
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Name: | Mephobarbital |
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Name (isomeric): | DB00849 |
Drug Type: | small molecule |
Description: | A barbiturate that is metabolized to PHENOBARBITAL. It has been used for similar purposes, especially in EPILEPSY, but there is no evidence mephobarbital offers any advantage over PHENOBARBITAL. |
Synonyms: |
Methylphenylbarbituric acid; Metilfenobarbitale [Dcit]; N-Ethylmethylphenylbarbituric acid; Methylphenobarbitonum; N-Methylphenobarbital; Mephobarbitone; Methylphenolbarbital; Methyl Phenobarbitone; Methylphenobarbitalum [INN-Latin]; N-Methylethylphenylbarbituric acid.
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Brand: | Prominal, Mebroin, Isonal, Metylfenemal, Enphenemal, Menta-Bal, Metyna, Mebaral, Morbusan, Phemitone, Phemetone, Methyl-Calminal, Enphenemalum, Phenmiton, Phemiton, Enfenemal, Meberal, Mephytal |
Category: | GABA Modulators, Hypnotics and Sedatives, Anticonvulsants |
CAS number: | 115-38-8 |
Indication: | For the relief of anxiety, tension, and apprehension, also used as an anticonvulsant for the treatment of epilepsy. |
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Pharmacology: |
Methylphenobarbital, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitati...
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Mechanism of Action: | Methylphenobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. |
Absorption: | Approximately 50% of an oral dose of mephobarbital is absorbed from the gastrointestinal tract. |
Protein binding: | 70-76% |
Biotransformation: | Hepatic, primarily by the hepatic microsomal enzyme system. About 75% of a single oral dose of mephobarbital is metabolized to phenobarbital in 24 hours. |
Half Life: | 34 (range 11-67) hours |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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