Name: | Methylprednisolone |
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PubChem Compound ID: | 11869640 |
Description: | A PREDNISOLONE derivative with similar anti-inflammatory action. |
Molecular formula: | C22H30O5 |
Molecular weight: | 374.471 g/mol |
Synonyms: |
ZINC03881944
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Name: | Methylprednisolone |
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Name (isomeric): | DB00959 |
Drug Type: | small molecule |
Description: | A PREDNISOLONE derivative with similar anti-inflammatory action. |
Synonyms: |
Methylprednisolon; Metilprednisolone [Dcit]; Metilprednisolona [INN-Spanish]; Methyleneprednisolone; Methylprednisolonum [INN-Latin]; 6alpha-Methylprednisolone
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Brand: | Medrol Dosepak, Wyacort, Metysolon, Suprametil, Medixon, Reactenol, Lemod, Mesopren, Moderin, Esametone, Promacortine, Besonia, Firmacort, Solomet, Dopomedrol, Predni N Tablinen, Nirypan, Artisone-Wyeth, Medesone, Urbasone, Urbason, Medrate, Medlone 21, Metilbetasone, Medrone, Medrol Adt Pak, Metastab, Metrocort, Metrisone, Summicort, Sieropresol, Noretona |
Brand name mixture: | Neo-Medrol(Methylprednisolone Acetate + Neomycin Sulfate), Methylprednisolone Sodium Succinate for Injection(Methylprednisolone + Water), Depo-Medrol with Lidocaine(Lidocaine Hydrochloride + Methylprednisolone Acetate), Medrol Acne Lotion(Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur), Neo-Medrol Acne Lotion(Aluminum Chlorohydrate... show more » |
Category: | Adrenergic Agents, Antiemetics, Glucocorticoids, Neuroprotective Agents, Anti-inflammatory Agents |
CAS number: | 83-43-2 |
Indication: | Adjunctive therapy for short-term administration in rheumatoid arthritis. |
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Pharmacology: | Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents. |
Mechanism of Action: |
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The an...
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Absorption: | Oral bioavailability 80-99% |
Protein binding: | 78% |
Biotransformation: | Hepatic |
Half Life: | 1-3 hours |
Toxicity: | LD50=2000 mg/kg (orally in rat) |
Affected organisms: | Humans and other mammals |
Drug interaction: |
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