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QuickView for Methylprednisolone (compound)

Name: Methylprednisolone
PubChem Compound ID: 11869640
Description: A PREDNISOLONE derivative with similar anti-inflammatory action.
Molecular formula: C22H30O5
Molecular weight: 374.471 g/mol
Name: Methylprednisolone
Name (isomeric): DB00959
Drug Type: small molecule
Description: A PREDNISOLONE derivative with similar anti-inflammatory action.
Methylprednisolon; Metilprednisolone [Dcit]; Metilprednisolona [INN-Spanish]; Methyleneprednisolone; Methylprednisolonum [INN-Latin]; 6alpha-Methylprednisolone
Brand: Medrol Dosepak, Wyacort, Metysolon, Suprametil, Medixon, Reactenol, Lemod, Mesopren, Moderin, Esametone, Promacortine, Besonia, Firmacort, Solomet, Dopomedrol, Predni N Tablinen, Nirypan, Artisone-Wyeth, Medesone, Urbasone, Urbason, Medrate, Medlone 21, Metilbetasone, Medrone, Medrol Adt Pak, Metastab, Metrocort, Metrisone, Summicort, Sieropresol, Noretona
Brand name mixture:
Neo-Medrol(Methylprednisolone Acetate + Neomycin Sulfate), Methylprednisolone Sodium Succinate for Injection(Methylprednisolone + Water), Depo-Medrol with Lidocaine(Lidocaine Hydrochloride + Methylprednisolone Acetate), Medrol Acne Lotion(Aluminum Chlorohydrate + Methylprednisolone Acetate + Sulfur), Neo-Medrol Acne Lotion(Aluminum Chlorohydrate...
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Category: Adrenergic Agents, Antiemetics, Glucocorticoids, Neuroprotective Agents, Anti-inflammatory Agents
CAS number: 83-43-2
Indication: Adjunctive therapy for short-term administration in rheumatoid arthritis.
Pharmacology: Methylprednisolone and its derivatives, methylprednisolone sodium succinate and methylprednisolone acetate, are synthetic glucocorticoids used as antiinflammatory or immunosuppressive agents.
Mechanism of Action:
Unbound glucocorticoids cross cell membranes and bind with high affinity to specific cytoplasmic receptors, modifying transcription and protein synthesis. By this mechanism, glucocorticoids can inhibit leukocyte infiltration at the site of inflammation, interfere with mediators of inflammatory response, and suppress humoral immune responses. The an...
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Absorption: Oral bioavailability 80-99%
Protein binding: 78%
Biotransformation: Hepatic
Half Life: 1-3 hours
Toxicity: LD50=2000 mg/kg (orally in rat)
Affected organisms: Humans and other mammals
Drug interaction:
ItraconazoleThe imidazole, itraconazole, may increase the effect and toxicity of the corticosteroid, methylprednisolone.
TrastuzumabTrastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
AprepitantIncreases the effect and toxicity of methylprednisolone
KetoconazoleThe imidazole, ketoconazole, may increase the effect and toxicity of the corticosteroid, methylprednisolone.
RifampinThe enzyme inducer, rifampin, may decrease the effect of the corticosteroid, methylprednisolone.
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