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QuickView for Metoclopramide (compound)
PubChem
| Name: | Metoclopramide |
|---|---|
| PubChem Compound ID: | 21761 |
| Description: | A dopamine D2 antagonist that is used as an antiemetic. |
| Molecular formula: | C14H24Cl3N3O2 |
| Molecular weight: | 372.717 g/mol |
| Synonyms: |
2576-84-3; Metoclopramide dihydrochloride; o-Anisamide, 4-amino-5-chloro-N-(2-(diethylamino)ethyl)-, dihydrochloride, monohydrate; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-o-anisamide dihydrochloride monohydrate; o-ANISAMIDE, 4-AMINO-5-CHLORO-N-(2-(DIETHYLAMINO)ETHYL)-, DIHYDROCHLORIDE, MONOH; 2-Methoxy-4-amino-5-chloro-N-(beta-(diethylamino)ethyl)benzamide dihydrochloride monohydrate; Metoclopramide dihydrochloride monohydrate; 364-62-5; 4-Amino-5-chloro-N-(2-(diethylamino)ethyl)-2-methoxybenzamide dihydrochloride; EINECS 219-926-3.
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DrugBank
Identification
| Name: | Metoclopramide |
|---|---|
| Name (isomeric): | DB01233 |
| Drug Type: | small molecule |
| Description: | A dopamine D2 antagonist that is used as an antiemetic. |
| Synonyms: |
Metoclopramidum [INN-Latin]; Metoclopramida [INN-Spanish]; Methochlopramide; Metochlopramide; Metaclopramide; Metoclopramide Hydrochloride; Metoclopramide Hcl; Methoclopramide; Metaclopromide
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| Brand: | Octamide, Nu-Metoclopramide, Gastrosil, Metamide, Reglan, Paspertin, Apo-Metoclop, Primperan, Pramidin, Clopra, Terperan, DEL, Parmid, Elieten, Clopra-Yellow, Peraprin, Duraclamid, Moriperan, Metramid, Pms-Metoclopramide, Maxolon, Meclopran, Metoclopramide Intensol, Metocobil, Eucil, Reclomide, Metoclopramide Omega, Emperal, Imperan, Reliveran, Metoclol, Emetid, Emitasol, Mygdalon, Gastro-Timelets, Pramiel, Gastrotem, Plasil, Neu-Sensamide, Gastrobid, Pramin, Clopromate, Gastronerton, Cerucal, Gastromax, Gastrese, Gastrotablinen, Maxeran |
| Category: | Antiemetics, Dopamine Antagonists, Prokinetic Agents |
| CAS number: | 364-62-5 |
Pharmacology
| Indication: | For the treatment of gastroesophageal reflux disease (GERD). It is also used in treating nausea and vomiting, and to increase gastric emptying. |
|---|---|
| Pharmacology: |
Metoclopramide, although chemically related to procainamide, does not possess local anesthetic or antiarrhythmic properties. Metoclopramide is used to enhance GI motility, to treat diabetic gastroparesis, as an antinauseant, and to facilitate intubation of the small bowel during radiologic examination. Metoclopramide may be used to treat chemothera...
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| Mechanism of Action: |
Metoclopramide inhibits gastric smooth muscle relaxation produced by dopamine, therefore increasing cholinergic response of the gastrointestinal smooth muscle. It accelerates intestinal transit and gastric emptying by preventing relaxation of gastric body and increasing the phasic activity of antrum. Simultaneously, this action is accompanied by re...
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| Absorption: | Rapidly and well absorbed (oral bioavailability 80±15.5%). |
| Protein binding: | 30% |
| Biotransformation: | Hepatic |
| Route of elimination: | Approximately 85% of the radioactivity of an orally administered dose appears in the urine within 72 hours. |
| Half Life: | 5-6 hr |
| Clearance: | 0.67 +/- 0.14 L/hr/kg [infants (0.9-5.4 months) with gastroesophageal reflux (GER)] |
| Toxicity: | Oral, mouse LD50: 280 mg/kg. Signs of overdose include drowsiness, disorientation, and extrapyramidal reactions. |
| Affected organisms: | Humans and other mammals |
Interactions
| Food interaction: |
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Targets
Enzymes
