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QuickView for Milnacipran (compound)
PubChem
| Name: | milnacipran |
|---|---|
| PubChem Compound ID: | 11622909 |
| Molecular formula: | C15H22N2O |
| Molecular weight: | 246.348 g/mol |
DrugBank
Identification
| Name: | milnacipran |
|---|---|
| Name (isomeric): | DB04896 |
| Drug Type: | small molecule |
| Synonyms: |
Milnacipranum [latin]; Midalcipran; (-)-milnacipran; F 2207
|
| Brand: | Toledomin, Ixel |
| Category: | Adrenergic Uptake Inhibitors, Serotonin Uptake Inhibitors, Antidepressive Agents |
| CAS number: | 92623-85-3 |
Pharmacology
| Indication: | Milnacipran is used to treat moderate to severe clinical depression and chronic pain. |
|---|---|
| Mechanism of Action: |
Milnacipran inhibits norepinephrine and serotonin reuptake in a 3:1 ratio, in practical use this means a balanced (equal) action upon both transmitters. The serotonin reuptake inhibition is likely to improve depression, while the norepinephrine reuptake inihibition probably improves chronic pain. Milnacipran exerts no significant actions on postyna...
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| Absorption: | Milnacipran is well absorbed following oral administration with an absolute bioavailability of 85%. Meals have no effect on absorption. |
| Biotransformation: | Only traces of active metabolites are found. Cytochrome P450 enzymes play no role in the metabolism of Milnacipran. |
| Route of elimination: | It is excreted predominantly unchanged in urine (55%) and has a terminal elimination half-life of about 6 to 8 hours. The main route of elimination of bepotastine besilate is urinary excretion (with approximately 75-90% excreted unchanged in urine). |
| Half Life: | 8 hours |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
