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QuickView for Mitomycin (compound)
PubChem
| Name: | Mitomycin |
|---|---|
| PubChem Compound ID: | 231224 |
| Description: | An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis. |
| Molecular formula: | C15H18N4O5 |
| Molecular weight: | 334.327 g/mol |
| Synonyms: |
50-07-7; Mit-C; NSC26980; Ametycin; MMC; Mitomycin; Ametycine; Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4, 7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8- (hydroxymethyl)-8a- methoxy-5-methyl-, carbamate (ester) (VAN 8CI); NCI-C04706; Mitomycinum.
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DrugBank
Identification
| Name: | Mitomycin |
|---|---|
| Name (isomeric): | DB00305 |
| Drug Type: | small molecule |
| Description: | An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis. |
| Synonyms: |
Mitamycin; MMC; 7-Amino-9α-methoxymitosane
|
| Brand: | Ametycin, Mitosol, Muamycin, Mitomycinum, Mitomycyna C [Polish], Mitocin-C, Mitomycin C, Mutamycin, Mytomycin, Mit-C, Mytozytrex, Mito-C, Ametycine, Mitomycinum C, Mitomycin (TN), Mitomycin-C, Mitozytrex |
| Category: | Cross-Linking Reagents, Antibiotics, Antineoplastic, Alkylating Agents, Nucleic Acid Synthesis Inhibitors |
| CAS number: | 50-07-7 |
Pharmacology
| Indication: | For treatment of malignant neoplasm of lip, oral cavity, pharynx, digestive organs, peritoneum, female breast, and urinary bladder. Also used as an adjunct to ab externo glaucoma surgery. |
|---|---|
| Pharmacology: |
Mitomycin is one of the older chemotherapy drugs, which has been around and in use for decades. It is an antibiotic which has been shown to have antitumor activity. Mitomycin selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of mitomycin-induced cross-linking. At high conc...
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| Mechanism of Action: | Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function. Mitomycin is cell cycle phase-nonspecific. |
| Absorption: | Erratic. |
| Biotransformation: | Primarily hepatic, some in various other tissues. |
| Route of elimination: | Approximately 10% of a dose of mitomycin is excreted unchanged in the urine. |
| Half Life: | 8-48 min |
| Toxicity: | Oral, mouse: LD50 = 23 mg/kg; Oral, rat: LD50 = 30 mg/kg. Symptoms of overdose include nausea and vomiting. |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
Enzymes
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