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PubChem
| Name: | Mitotane |
|---|---|
| PubChem Compound ID: | 10245495 |
| Description: | A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. |
| Molecular formula: | C14H10Cl4 |
| Molecular weight: | 321.046 g/mol |
DrugBank
Identification
| Name: | Mitotane |
|---|---|
| Name (isomeric): | DB00648 |
| Drug Type: | small molecule |
| Description: | A derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors and causes CNS damage, but no bone marrow depression. |
| Brand: | Mitotanum [INN-Latin], Lysodren, Mitotan, Chlodithane, Chloditan, Khlodithan, Chlodithan |
| Category: | Antineoplastic Agents, Hormonal, Antineoplastic Agents |
| CAS number: | 53-19-0 |
Pharmacology
| Indication: | For treatment of inoperable adrenocortical tumours; Cushing's syndrome |
|---|---|
| Pharmacology: |
Mitotane is an oral chemotherapeutic agent indicated in the treatment of inoperable adrenal cortical carcinoma of both functional and nonfunctional types. Mitotane can best be described as an adrenal cytotoxic agent, although it can cause adrenal inhibition, apparently without cellular destruction. The administration of Mitotane alters the extra-ad...
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| Mechanism of Action: | Its biochemical mechanism of action is unknown, although data are available to suggest that the drug modifies the peripheral metabolism of steroids as well as directly suppressing the adrenal cortex. |
| Absorption: | About 40% oral Lysodren is absorbed |
| Protein binding: | 6% |
| Biotransformation: | Hepatic and renal |
| Route of elimination: | A variable amount of metabolite (1%-17%) is excreted in the bile and the balance is apparently stored in the tissues. |
| Half Life: | 18-159 days |
| Affected organisms: | Humans and other mammals |
Interactions
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