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QuickView for Molindone (compound)
PubChem
| Name: | Molindone |
|---|---|
| PubChem Compound ID: | 23897 |
| Description: | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283) |
| Molecular formula: | C16H24N2O2 |
| Molecular weight: | 276.374 g/mol |
| Synonyms: |
3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one; Prestwick0_001035; Prestwick1_001035; 7416-34-4; Molindonum [INN-Latin]; Indol-4(5H)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-; HSDB 3131; Molindona [INN-Spanish]; Molindone; (+-)-Molindone.
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DrugBank
Identification
| Name: | Molindone |
|---|---|
| Name (isomeric): | DB01618 |
| Drug Type: | small molecule |
| Description: | An indole derivative effective in schizophrenia and other psychoses and possibly useful in the treatment of the aggressive type of undersocialized conduct disorder. Molindone has much lower affinity for D2 receptors than most antipsychotic agents and has a relatively low affinity for D1 receptors. It has only low to moderate affinity for cholinergic and alpha-adrenergic receptors. Some electrophysiologic data from animals indicate that molindone has certain characteristics that resemble those of CLOZAPINE. (From AMA Drug Evaluations Annual, 1994, p283) |
| Synonyms: |
Molindona [inn-spanish]; Molindonum [inn-latin]; (+-)-molindone
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| Brand: | Moban |
| Category: | Antipsychotic Agents |
| CAS number: | 7416-34-4 |
Pharmacology
| Indication: | Molindone is used for the management of the manifestations of psychotic disorders. |
|---|---|
| Pharmacology: |
Molindone is a dihydroindolone compound which is not structurally related to the phenothiazines, the butyrophenones, or the thioxanthenes. Molindone has a pharmacological profile in laboratory animals which predominantly resembles that of major tranquilizers causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditione...
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| Mechanism of Action: |
The exact mechanism has not been established, however, based on electroencephalogram (EEG) studies, molindone is thought to act by occupying (antagonizing) dopamine (D2) receptor sites in the reticular limbic systems in the brain, thus decreasing dopamine activity. Decreased dopamine activity results in decreased physiological effects normally indu...
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| Absorption: | Rapidly absorbed from the gastrointestinal tract following oral administration. |
| Biotransformation: | Most likely hepatic. 36 metabolites have been recognized, some of which may be active. |
| Route of elimination: | Human metabolic studies show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites with less than 2-3% unmetabolized molindone being excreted in urine and feces. |
| Affected organisms: | Humans and other mammals |
Interactions
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Targets
