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QuickView for Moxifloxacin (compound)

Name: moxifloxacin
PubChem Compound ID: 101526
Molecular formula: C21H25ClFN3O4
Molecular weight: 437.892 g/mol
3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-((4aS,7aS)-octahydro-6H-pyrrolo(3,4-b)pyridin-6-yl)-4-oxo-, monohydrochloride; Izilox; Vegamox; BAY 12-8039; Moxifloxacin hydrochloride [USAN]; Moxiflocacin hydrochloride; Moxifloxacin hydrochloride; 186826-86-8; Actira; LS-173737.
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Name: moxifloxacin
Name (isomeric): DB00218
Drug Type: small molecule
Moxifloxacin hydrochloride; Moxifloxacin HCl; BAY 12-8039
Brand: Avelox I.V., Avelox, Vigamox
Category: Anti-Bacterial Agents, Anti-Infective Agents, Quinolones
CAS number: 354812-41-2
Indication: For the treatment of sinus and lung infections such as sinusitis, pneumonia, and secondary infections in chronic bronchitis. Also for the treatment of bacterial conjunctivitis (pinkeye).
Moxifloxacin is a quinolone/fluoroquinolone antibiotic. Moxifloxacin can be used to treat infections caused by the following bacteria: Aerobic Gram-positive microorganisms: Corynebacterium species, Micrococcus luteus, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus haemolyticus, Staphylococcus...
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Mechanism of Action:
The bactericidal action of moxifloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV. DNA gyrase is an essential enzyme that is involved in the replication, transcription and repair of bacterial DNA. Topoisomerase IV is an enzyme known to play a key role in the partitioning of the chromosomal DNA during ...
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Absorption: Well absorbed from the gastrointestinal tract. Absolute oral bioavailability is approximately 90%. Food has little effect on absorption.
Protein binding: 50% bound to serum proteins, independent of drug concentration.
Biotransformation: Approximately 52% or oral or intravenous dose is metabolized via glucuronide and sulphate conjugation. The cytochrome P450 system is not involved in metabolism. The sulphate conjugate accounts for 38% of the dose, and the glucuronide conjugate accounts for 14% of the dose.
Route of elimination: Approximately 45% of an oral or intravenous dose of moxifloxacin is excreted as unchanged drug (~20% in urine and ~25% in feces).
Half Life: 11.5-15.6 hours (single dose, oral)
Clearance: 12 +/- 2 L/hr
Toxicity: Symptoms of overdose include CNS and gastrointestinal effects such as decreased activity, somnolence, tremor, convulsions, vomiting, and diarrhea. The minimal lethal intravenous dose in mice and rats is 100 mg/kg.
Affected organisms: Enteric bacteria and other eubacteria
Food interaction:
Take without regard to meals. Drink liberally. Absorption is not affected by lipid-rich meals or yogourt.
Drug interaction:
ErythromycinIncreased risk of cardiotoxicity and arrhythmias
DisopyramideIncreased risk of cardiotoxicity and arrhythmias
IronFormation of non-absorbable complexes
CalciumFormation of non-absorbable complexes
BretyliumIncreased risk of cardiotoxicity and arrhythmias
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