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QuickView for Mre11 (gene)


Gene Symbol:
MRE11 Homo sapiens Homo sapiens
Full name:
MRE11 homolog, double strand break repair nuclease
Synonyms:
ATLD, HNGS1, MRE11A, MRE11B, double-strand break repair protein MRE11, double-strand break repair protein MRE11A, AT-like disease, DNA recombination and repair protein, MRE11 double strand break repair nuclease A, MRE11 homolog 1, MRE11 homolog A, double strand break repair nuclease, MRE11 homolog, double strand break repair nuclease A, MRE11 meiotic recombination 11 homolog A, MRE11 meiotic recombination 11-like protein A, endo/exonuclease Mre11, meiotic recombination 11 homolog 1, meiotic recombination 11 homolog A
Genomic Location:
Chr 11: 93790114-93866688
Description:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesse...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Danio rerio Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 11
11q21





GO Molecular Function

sequence-specific DNA binding | nuclease activity | sequence-specific single stranded DNA binding | single-stranded DNA endodeoxyribonuclease activity | cadherin binding | cation binding | nucleic acid binding | ATP-dependent DNA helicase activity | hydrolase activity | single-stranded DNA binding | ATPase activity | pyrophosphatase activity | catalytic activity | nucleoside-triphosphatase activity | ATPase activity, coupled | deoxyribonuclease activity | DNA binding | hydrolase activity, acting on ester bonds | identical protein binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | double-stranded telomeric DNA binding | endodeoxyribonuclease activity | cell adhesion molecule binding | DNA helicase activity | protein binding | double-stranded DNA binding | manganese ion binding | 3'-5' exonuclease activity | hydrolase activity, acting on acid anhydrides | endonuclease activity | transition metal ion binding | single-stranded telomeric DNA binding | DNA-dependent ATPase activity | helicase activity | exonuclease activity | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | telomeric DNA binding | protein C-terminus binding

GO Biological Process

double-strand break repair | intra-S DNA damage checkpoint | regulation of cell cycle process | telomere maintenance | positive regulation of cellular component organization | nuclease activity | regulation of programmed cell death | negative regulation of cellular process | telomere capping | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | negative regulation of DNA metabolic process | cellular process | telomere maintenance via telomerase | synapsis | single-stranded DNA endodeoxyribonuclease activity | mitotic DNA integrity checkpoint | negative regulation of apoptotic process | regulation of cell cycle | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | interspecies interaction between organisms | DNA geometric change | anatomical structure homeostasis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | ATP-dependent DNA helicase activity | negative regulation of DNA replication | regulation of type I interferon production | response to stimulus | regulation of DNA recombination | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | response to stress | negative regulation of G2/M transition of mitotic cell cycle | cellular nitrogen compound biosynthetic process | mitotic G2 DNA damage checkpoint | regulation of cell cycle phase transition | reproduction | cellular nitrogen compound metabolic process | telomere organization | double-strand break repair via nonhomologous end joining | nucleic acid phosphodiester bond hydrolysis | negative regulation of metabolic process | cellular biosynthetic process | DNA recombination | telomere maintenance via telomere lengthening | meiotic chromosome segregation | DNA repair | regulation of cell cycle G2/M phase transition | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | double-strand break repair via homologous recombination | mitotic DNA damage checkpoint | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | cellular response to DNA damage stimulus | regulation of telomere maintenance | regulation of catalytic activity | regulation of phosphorylation | positive regulation of chromosome organization | DNA biosynthetic process | cellular response to stress | DNA double-strand break processing | cell cycle | regulation of protein autophosphorylation | RNA-dependent DNA biosynthetic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | deoxyribonuclease activity | mitochondrial double-strand break repair via homologous recombination | regulation of nitrogen compound metabolic process | regulation of DNA endoreduplication | cell proliferation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | regulation of DNA-dependent DNA replication | DNA duplex unwinding | nuclear chromosome segregation | DNA strand elongation | regulation of cellular metabolic process | negative regulation of DNA endoreduplication | endodeoxyribonuclease activity | regulation of protein metabolic process | base-excision repair | homeostatic process | regulation of protein phosphorylation | meiotic DNA double-strand break formation | viral process | regulation of mitotic cell cycle | DNA helicase activity | positive regulation of molecular function | mitotic G2/M transition checkpoint | homologous chromosome segregation | positive regulation of protein modification process | telomeric 3' overhang formation | negative regulation of DNA-dependent DNA replication | regulation of kinase activity | DNA metabolic process | reciprocal meiotic recombination | mitotic cell cycle | nuclear division | metabolic process | 3'-5' exonuclease activity | negative regulation of programmed cell death | regulation of mitotic recombination | negative regulation of mitotic cell cycle | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | endonuclease activity | positive regulation of kinase activity | regulation of phosphate metabolic process | regulation of chromosome organization | chromosome organization involved in meiotic cell cycle | positive regulation of cytokine production | meiosis I | negative regulation of cell cycle | meiotic cell cycle | positive regulation of phosphorylation | regulation of cytokine production | cellular macromolecule biosynthetic process | homologous recombination | positive regulation of telomere maintenance | positive regulation of DNA metabolic process | recombinational repair | organelle organization | sister chromatid cohesion | positive regulation of protein autophosphorylation | exonuclease activity | DNA conformation change | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of cell death | positive regulation of type I interferon production | DNA damage checkpoint | cell cycle checkpoint | DNA replication | negative regulation of cell death | regulation of cellular component organization | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

site of DNA damage | chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | protein-containing complex | PML body | nucleoplasm | chromatin | nuclear chromosome | chromosome, telomeric region | site of double-strand break | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | nuclear chromosome, telomeric region | intracellular | Mre11 complex