QuickView for Mtr4 (gene)
- Gene Symbol:
- MTR4
Saccharomyces cerevisiae - Full name:
- Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA
- Synonyms:
- DOB1, MTR4, Mtr4, YJL050W
- Genomic Location:
- Chr X: 342517-345738
- Orthologs:
- Homo sapiens , Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
GO Molecular Function
ATP-dependent RNA helicase activity | 3'-5' RNA helicase activity | RNA-dependent ATPase activity | nucleic acid binding | ribonucleotide binding | poly(A) binding | mRNA binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | catalytic activity | ATP-dependent 3'-5' RNA helicase activity | ATP binding | anion binding | adenyl nucleotide binding | single-stranded RNA binding | nucleoside-triphosphatase activity | ATPase activity, coupled | purine nucleotide binding | ATP-dependent helicase activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | poly-purine tract binding | RNA helicase activity | hydrolase activity, acting on acid anhydrides | purine ribonucleotide binding | adenyl ribonucleotide binding | helicase activity | drug binding | heterocyclic compound binding | oxidoreductase activity | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | small molecule binding | RNA binding
GO Biological Process
RNA metabolic process | RNA surveillance | snRNA metabolic process | RNA processing | nuclear export | exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | establishment of localization | nuclear retention of pre-mRNA at the site of transcription | intracellular transport | cellular process | organic substance catabolic process | localization | maturation of 5.8S rRNA | protein transport | macromolecule localization | ribosome biogenesis | establishment of localization in cell | polyadenylation-dependent mRNA catabolic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | mRNA catabolic process | protein export from nucleus | intracellular mRNA localization | intracellular protein transport | snoRNA metabolic process | ncRNA 3'-end processing | ncRNA processing | cellular localization | cellular nitrogen compound metabolic process | nuclear RNA surveillance | nucleic acid phosphodiester bond hydrolysis | polyadenylation-dependent snoRNA 3'-end processing | negative regulation of metabolic process | poly(A)+ mRNA export from nucleus | mRNA metabolic process | nuclear-transcribed mRNA catabolic process | nucleobase-containing compound catabolic process | mRNA export from nucleus | RNA polyadenylation | snoRNA 3'-end processing | nitrogen compound metabolic process | ribonucleoprotein complex localization | tRNA catabolic process | nuclear polyadenylation-dependent tRNA catabolic process | U4 snRNA 3'-end processing | regulation of gene expression | organic substance transport | RNA catabolic process | nuclear polyadenylation-dependent ncRNA catabolic process | peptide transport | nuclear mRNA surveillance | nuclear polyadenylation-dependent rRNA catabolic process | cleavage involved in rRNA processing | U5 snRNA 3'-end processing | RNA export from nucleus | mRNA transport | establishment of RNA localization | rRNA metabolic process | rRNA catabolic process | snRNA processing | protein-containing complex localization | aromatic compound catabolic process | polyadenylation-dependent RNA catabolic process | rRNA processing | nuclear mRNA surveillance of mRNA 3'-end processing | tRNA metabolic process | snRNA 3'-end processing | rRNA 3'-end processing | cellular macromolecule catabolic process | nucleobase-containing compound transport | metabolic process | RNA 3'-end processing | oxidation-reduction process | cellular protein localization | amide transport | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | negative regulation of gene expression | RNA phosphodiester bond hydrolysis | gene expression | ncRNA polyadenylation | establishment of protein localization | RNA phosphodiester bond hydrolysis, exonucleolytic | RNA transport | nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription | protein localization | cellular macromolecule localization | nucleocytoplasmic transport | maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | ncRNA metabolic process | heterocycle metabolic process | snoRNA processing | ribonucleoprotein complex biogenesis | nuclear polyadenylation-dependent mRNA catabolic process | cellular metabolic process | oxidoreductase activity | RNA localization | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular organelle | TRAMP complex | protein-containing complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
