QuickView for Myo15a (gene)

Gene Symbol:

MYO15A Homo sapiens

Full name:

myosin XVA

Synonyms:

DFNB3, MYO15, unconventional myosin-XV, myosin-XV, unconventional myosin-15

Genomic Location:

Chr 17: 17952745-18023841

Description:

This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, ne...

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This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YAATNRNNNYNATT_UNKNOWN ,  AP2_Q3 ,  POU1F1_Q6 ,  YCATTAA_UNKNOWN ,  TEF_Q6 ,  MMEF2_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-491

Cytogenetic Map:

17p11.2

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