QuickView for N-CoR (gene)
- Gene Symbol:
- NCOR1
Homo sapiens - Full name:
- nuclear receptor corepressor 1
- Synonyms:
- N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR, nuclear receptor corepressor 1, protein phosphatase 1, regulatory subunit 109, thyroid hormone- and retinoic acid receptor-associated corepressor 1
- Genomic Location:
- Chr 17: 15875983-16059570
- Description:
-
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Si...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
17p12-p11.2
GO Molecular Function
transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | hormone receptor binding | enzyme binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | signaling receptor binding | thyroid hormone receptor binding | DNA binding | transcription corepressor activity | nuclear hormone receptor binding | organic cyclic compound binding | protein binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | nuclear receptor binding | histone deacetylase binding | transcription coregulator activity | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | negative regulation of JNK cascade | regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter | negative regulation of phosphorylation | negative regulation of MAPK cascade | regulation of localization | regulation of carbohydrate metabolic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | negative regulation of protein phosphorylation | negative regulation of gene silencing by RNA | regulation of lipid transport | microtubule-based process | negative regulation of stress-activated protein kinase signaling cascade | cellular process | regulation of production of miRNAs involved in gene silencing by miRNA | regulation of glycolytic process | chromatin organization | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | spindle assembly | negative regulation of cellular metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of gene silencing by miRNA | cellular component organization | cellular nitrogen compound biosynthetic process | circadian rhythm | rhythmic process | regulation of gene silencing | cellular nitrogen compound metabolic process | negative regulation of metabolic process | cellular component assembly | cellular biosynthetic process | regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | organelle assembly | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | regulation of MAPK cascade | regulation of phosphorylation | regulation of gene expression | negative regulation of gene silencing by miRNA | cell cycle | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of stress-activated MAPK cascade | regulation of cellular metabolic process | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of RNA metabolic process | negative regulation of gene silencing | DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter | regulation of gene silencing by RNA | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | negative regulation of cellular protein metabolic process | gene expression | regulation of ATP metabolic process | regulation of phosphate metabolic process | cytoskeleton organization | transcription, DNA-templated | regulation of JNK cascade | negative regulation of protein metabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | negative regulation of signal transduction | regulation of transcription, DNA-templated | regulation of production of small RNA involved in gene silencing by RNA | cellular macromolecule biosynthetic process | regulation of ion transport | organelle organization | negative regulation of transcription by RNA polymerase II | regulation of transport | regulation of fatty acid transport | transcription coregulator activity | heterocycle metabolic process | regulation of anion transport | regulation of generation of precursor metabolites and energy | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | spindle organization | regulation of signaling | positive regulation of gene expression | negative regulation of production of miRNAs involved in gene silencing by miRNA | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
supramolecular fiber | chromosome | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | microtubule | cytoplasm | spindle | intracellular organelle | protein-containing complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | microtubule cytoskeleton | Sin3 complex | spindle microtubule | membrane-bounded organelle | transcriptional repressor complex | nucleus | Sin3-type complex | organelle | membrane-enclosed lumen | nuclear chromatin | cytosol | cytoskeleton | intracellular | membrane | supramolecular complex
