QuickView for N-Ras (gene)

Gene Symbol:

NRAS Homo sapiens

Full name:

NRAS proto-oncogene, GTPase

Synonyms:

ALPS4, CMNS, N-ras, NCMS, NRAS1, NS6, GTPase NRas, N-ras protein part 4, neuroblastoma RAS viral (v-ras) oncogene homolog, neuroblastoma RAS viral oncogene homolog, transforming protein N-Ras, v-ras neuroblastoma RAS viral oncogene homolog

Genomic Location:

Chr 1: 115051108-115061038

Description:

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated ...

View Full Description

This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  SP1_01 ,  IRF1_01 ,  GABP_B ,  RTAAACA_FREAC2_01 ,  PAX4_04 ,  FREAC7_01 ,  HNF3ALPHA_Q6 ,  STAT4_01 ,  TGANTCA_AP1_C ,  GATA1_03 ,  OCT1_B ,  USF_Q6 ,  STAT1_02 ,  FOXJ2_02 ,  MAZ_Q6 ,  MYC_Q2 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  POU3F2_01 ,  CACGTG_MYC_Q2 ,  NKX3A_01 ,  GCANCTGNY_MYOD_Q6 ,  FOXD3_01 ,  AAANWWTGC_UNKNOWN ,  EVI1_04 ,  WGTTNNNNNAAA_UNKNOWN ,  SRY_01 ,  MEIS1BHOXA9_01 ,  IRF1_Q6 ,  OCT1_Q5_01 ,  OCT_C ,  AML1_01 ,  WTGAAAT_UNKNOWN ,  OSF2_Q6 ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  EVI1_03 ,  FOXO3_01 ,  CEBP_01 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  AGCTCCT_MIR28 ,  YY1_01 ,  EVI1_02 ,  HNF3_Q6 ,  EVI1_05 ,  RRAGTTGT_UNKNOWN ,  ACTACCT_MIR196A_MIR196B ,  MYCMAX_01 ,  GGGCGGR_SP1_Q6 ,  AP1_Q2_01 ,  GATA6_01 ,  GCGNNANTTCC_UNKNOWN ,  AAGWWRNYGGC_UNKNOWN ,  MGGAAGTG_GABP_B ,  EVI1_06 ,  HFH4_01 ,  AP1_Q4 ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  RNGTGGGC_UNKNOWN ,  NCX_01 ,  GTGCCTT_MIR506 ,  NMYC_01 ,  AML1_Q6 ,  EN1_01 ,  BACH1_01 ,  CETS1P54_01 ,  USF_Q6_01 ,  POU3F2_02 ,  TTGTTT_FOXO4_01 ,  CART1_01 ,  SCGGAAGY_ELK1_02 ,  STAT5A_04 ,  WWTAAGGC_UNKNOWN ,  NRF2_01 ,  CTGCAGY_UNKNOWN ,  SRF_Q5_01 ,  AP1_Q2 ,  WCAANNNYCAG_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CDC5_01 ,  ELK1_02 ,  USF2_Q6 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  AP1_Q4_01 ,  COREBINDINGFACTOR_Q6 ,  CEBPGAMMA_Q6 ,  HNF6_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-505

miRNA binding sites
(Source: miRecords):

hsa-let-7a Targeted Genes

Cytogenetic Map:

1p13.2

search → result