QuickView for N-WASP (gene)

Gene Symbol:

WASL Homo sapiens

Full name:

Wiskott-Aldrich syndrome like

Synonyms:

N-WASP, NWASP, WASPB, neural Wiskott-Aldrich syndrome protein

Genomic Location:

Chr 7: 123109233-123176352

Description:

This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeleta...

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This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  NFMUE1_Q6 ,  GCCATNTTG_YY1_Q6 ,  MYAATNNNNNNNGGC_UNKNOWN ,  CAGGTG_E12_Q6 ,  TTCYRGAA_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  SOX5_01 ,  YY1_02 ,  KMCATNNWGGA_UNKNOWN ,  TGATTTRY_GFI1_01 ,  SRY_02 ,  AACTTT_UNKNOWN ,  HNF6_Q6 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

7q31.32

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