NAD(P)-binding domain superfamily QuickView

Description:: This entry represents NAD- and NADP-binding domains superfamily with a core Rossmann-type fold, which consists of three layers (alpha/beta/alpha) with parallel beta-sheet of 6 strands. Many different enzymes contain an NAD/NADP-binding domain, including:C-terminal domain of alcohol dehydrogenasesTyrosine-dependent oxidoreductases (also known as short-chain dehydrogenases)N-terminal domain of glyceraldehyde-3-phosphate dehydrogenaseNAD-binding domain of formate/glycerate dehydrogenasesN-terminal domain of sirohaem synthaseN-terminal domain of lactate dehydrogenaseN-terminal domain of 6-phosphogluconate dehydrogenase (the beta-sheet is extended to 8 strands)C-terminal domain of amino acid dehydrogenases (an extra N-terminal helix displaces the C-terminal helixNAD-binding domain of certain potassium channelsC-terminal domain of the transcriptional repressor RexOrnithine cyclodeaminaseCoA-binding N-terminal domain of the alpha chain of succinyl-CoA synthetase