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QuickView for NADH (compound)


PubChem
Name: NAD
PubChem Compound ID: 10508752
Description: A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Molecular formula: C21H28N7O14P2+
Molecular weight: 665.439 g/mol
DrugBank
Identification
Name: NAD
Name (isomeric): DB00157
Drug Type: small molecule
Description: A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
Synonyms:
Coenzyme I, reduced; DPN; DPNH; NADH+H+; Nicotinaminde-Adenine-Dinucleotide; DPN+; Diphosphopyridine nucleotide; NAD-reduced; nicotinamide adenine dinucleotide reduced; NADH2.
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Brand: Nadide
Category: Micronutrient, Dietary supplement
CAS number: 606-68-8
Pharmacology
Indication: Some evidence suggests that NADH might be useful in treating Parkinson's disease, chronic fatigue syndrome, Alzheimer's disease and cardiovascular disease.
Pharmacology:
A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). The action of supplemental NADH is unclear. Oral NADH su...
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Mechanism of Action:
NADH is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeab...
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Absorption: Unclear how much of an administered dose is absorbed.
Toxicity: No reports of overdose, however, high doses of NADH (10 mg a day or more) may cause jitteriness, anxiety, and insomnia.
Affected organisms: Humans and other mammals

Targets


Enzymes