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QuickView for NANOG (gene)


Gene Symbol:
NANOG Homo sapiens Homo sapiens
Full name:
Nanog homeobox
Synonyms:
homeobox protein NANOG, homeobox transcription factor Nanog, homeobox transcription factor Nanog-delta 48
Genomic Location:
Chr 12: 7833262-7839922
Description:
The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 12
12p13.31





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nucleic acid binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription coregulator activity | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of macromolecule biosynthetic process | response to cytokine | somatic stem cell population maintenance | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | cell differentiation | positive regulation of cellular biosynthetic process | cellular process | cell fate specification | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | endodermal cell fate commitment | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | embryo development | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | cytokine-mediated signaling pathway | transcription corepressor activity | regulation of transcription by RNA polymerase II | endoderm formation | cellular response to cytokine stimulus | cell proliferation | biosynthetic process | aromatic compound biosynthetic process | endodermal cell fate specification | cell communication | regulation of cellular metabolic process | regulation of RNA metabolic process | embryonic morphogenesis | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | response to organic substance | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | gene expression | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | signaling | regulation of transcription, DNA-templated | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | regulation of developmental process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | gastrulation | cellular metabolic process | cellular response to organic substance | signal transduction | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | nucleolus | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular