QuickView for NDUFS1 (gene)
- Gene Symbol:
- NDUFS1
Homo sapiens - Full name:
- NADH:ubiquinone oxidoreductase core subunit S1
- Synonyms:
- CI-75Kd, CI-75k, PRO1304, NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial, NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase), complex I 75kDa subunit, complex I, mitochondrial respiratory chain, 75-kD subunit, mitochondrial NADH-ubiquinone oxidoreductase 75 kDa subunit
- Genomic Location:
- Chr 2: 206696048-206732432
- Description:
-
The protein encoded by this gene belongs to the complex I 75 kDa subunit family. Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron accepto...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Bos taurus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
CRGAARNNNNCGA_UNKNOWN , PR_02 , PPARG_01 , USF_Q6 , CACGTG_MYC_Q2 , MAX_01 , COUP_01 , GCCATNTTG_YY1_Q6 , MYCMAX_B , HNF4_DR1_Q3
- Cytogenetic Map:
-
2q33.3
GO Molecular Function
oxidoreductase activity, acting on NAD(P)H | cofactor binding | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | cation binding | catalytic activity | electron transfer activity | iron-sulfur cluster binding | ion binding | protein binding | NADH dehydrogenase activity | 2 iron, 2 sulfur cluster binding | 4 iron, 4 sulfur cluster binding | NADH dehydrogenase (ubiquinone) activity | metal ion binding | oxidoreductase activity
GO Biological Process
purine ribonucleotide metabolic process | oxidoreductase activity, acting on NAD(P)H | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | reactive oxygen species metabolic process | generation of precursor metabolites and energy | cellular process | regulation of mitochondrial membrane potential | nucleotide metabolic process | ATP synthesis coupled electron transport | cellular respiration | ribose phosphate metabolic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | organic cyclic compound metabolic process | mitochondrial respiratory chain complex assembly | cellular aromatic compound metabolic process | cellular component organization | purine nucleotide metabolic process | mitochondrial respiratory chain complex I assembly | electron transport chain | programmed cell death | cellular nitrogen compound metabolic process | apoptotic mitochondrial changes | cellular component assembly | mitochondrion organization | regulation of membrane potential | apoptotic process | nitrogen compound metabolic process | phosphorus metabolic process | electron transfer activity | organophosphate metabolic process | NADH dehydrogenase complex assembly | small molecule metabolic process | nucleobase-containing small molecule metabolic process | phosphorylation | cellular protein-containing complex assembly | phosphate-containing compound metabolic process | mitochondrial ATP synthesis coupled electron transport | drug metabolic process | protein-containing complex assembly | NADH dehydrogenase activity | metabolic process | oxidation-reduction process | oxidative phosphorylation | nucleobase-containing compound metabolic process | organic substance metabolic process | cell death | NADH dehydrogenase (ubiquinone) activity | energy derivation by oxidation of organic compounds | organelle organization | carbohydrate derivative metabolic process | mitochondrial electron transport, NADH to ubiquinone | heterocycle metabolic process | cellular metabolic process | ATP metabolic process | oxidoreductase activity | respiratory electron transport chain
GO Cellular Component
mitochondrial matrix | mitochondrial intermembrane space | organelle inner membrane | intracellular membrane-bounded organelle | catalytic complex | mitochondrial inner membrane | organelle membrane | cell | oxidoreductase complex | plasma membrane protein complex | mitochondrial respiratory chain complex I | cytoplasm | respiratory chain complex I | intracellular organelle | protein-containing complex | plasma membrane | mitochondrial respiratory chain | respiratory chain | mitochondrion | membrane-bounded organelle | organelle | mitochondrial envelope | cell periphery | membrane-enclosed lumen | mitochondrial membrane | intracellular | myelin sheath | membrane | plasma membrane respiratory chain complex I
