QuickView for NDUFS2 (gene)
- Gene Symbol:
- NDUFS2
Homo sapiens - Full name:
- NADH:ubiquinone oxidoreductase core subunit S2
- Synonyms:
- CI-49, NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial, CI-49kD, NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase), NADH-ubiquinone oxidoreductase 49 kDa subunit, NADH-ubiquinone oxidoreductase NDUFS2 subunit, complex 1, mitochondrial respiratory chain, 49-KD subunit, complex I 49kDa subunit, complex I-49kD
- Genomic Location:
- Chr 1: 159435729-159450809
- Description:
-
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of co...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Bos taurus , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
TGGAAA_NFAT_Q4_01 , DR3_Q4 , ETS_Q4 , TTANTCA_UNKNOWN , RYTTCCTG_ETS2_B , SMAD3_Q6 , PEA3_Q6 , LXR_DR4_Q3 , TEL2_Q6 , VDR_Q6
- Cytogenetic Map:
-
1q23.3
GO Molecular Function
oxidoreductase activity, acting on NAD(P)H | cofactor binding | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | cation binding | enzyme binding | nucleotide binding | coenzyme binding | catalytic activity | ubiquitin-like protein ligase binding | electron transfer activity | iron-sulfur cluster binding | ion binding | organic cyclic compound binding | protein binding | NADH dehydrogenase activity | ubiquitin protein ligase binding | NAD binding | 4 iron, 4 sulfur cluster binding | NADH dehydrogenase (ubiquinone) activity | quinone binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
purine ribonucleotide metabolic process | oxidoreductase activity, acting on NAD(P)H | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | generation of precursor metabolites and energy | cellular process | nucleotide metabolic process | ATP synthesis coupled electron transport | cellular respiration | ribose phosphate metabolic process | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | organic cyclic compound metabolic process | mitochondrial respiratory chain complex assembly | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | purine nucleotide metabolic process | response to stress | mitochondrial respiratory chain complex I assembly | electron transport chain | cellular nitrogen compound metabolic process | cellular component assembly | mitochondrion organization | nitrogen compound metabolic process | phosphorus metabolic process | electron transfer activity | organophosphate metabolic process | NADH dehydrogenase complex assembly | small molecule metabolic process | response to oxidative stress | nucleobase-containing small molecule metabolic process | phosphorylation | cellular protein-containing complex assembly | phosphate-containing compound metabolic process | mitochondrial ATP synthesis coupled electron transport | drug metabolic process | protein-containing complex assembly | NADH dehydrogenase activity | metabolic process | oxidation-reduction process | oxidative phosphorylation | nucleobase-containing compound metabolic process | organic substance metabolic process | NADH dehydrogenase (ubiquinone) activity | energy derivation by oxidation of organic compounds | organelle organization | carbohydrate derivative metabolic process | mitochondrial electron transport, NADH to ubiquinone | heterocycle metabolic process | cellular metabolic process | ATP metabolic process | oxidoreductase activity | respiratory electron transport chain
GO Cellular Component
mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | catalytic complex | mitochondrial inner membrane | organelle membrane | cell | oxidoreductase complex | nuclear lumen | mitochondrial respiratory chain complex I | cytoplasm | respiratory chain complex I | intracellular organelle | protein-containing complex | nucleoplasm | mitochondrial respiratory chain | respiratory chain | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | membrane
