QuickView for NEDD4 (gene)

Gene Symbol:

NEDD4 Homo sapiens

Full name:

neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase

Synonyms:

NEDD4-1, RPF1, E3 ubiquitin-protein ligase NEDD4, HECT-type E3 ubiquitin transferase NEDD4, cell proliferation-inducing gene 53 protein, receptor-potentiating factor 1

Genomic Location:

Chr 15: 53906412-54073127

Description:

This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It pla...

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This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  OCT1_07 ,  RTAAACA_FREAC2_01 ,  FREAC7_01 ,  TGIF_01 ,  STAT4_01 ,  PR_02 ,  OCT1_B ,  ETS_Q4 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  RSRFC4_01 ,  HFH3_01 ,  OCT1_01 ,  YATGNWAAT_OCT_C ,  YTATTTTNR_MEF2_02 ,  NKX3A_01 ,  AAAYWAACM_HFH4_01 ,  HFH1_01 ,  EVI1_04 ,  RSRFC4_Q2 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  AMEF2_Q6 ,  IRF1_Q6 ,  NKX22_01 ,  OCT_C ,  ACTGTGA_MIR27A_MIR27B ,  WTGAAAT_UNKNOWN ,  TATAAA_TATA_01 ,  CEBPDELTA_Q6 ,  OCT1_Q6 ,  FOXO3_01 ,  MEF2_01 ,  YYCATTCAWW_UNKNOWN ,  FREAC3_01 ,  TATA_C ,  HNF3B_01 ,  ACCAAAG_MIR9 ,  IRF_Q6 ,  CTTTAAR_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  HFH8_01 ,  ATACTGT_MIR144 ,  HMEF2_Q6 ,  STAT_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  WGGAATGY_TEF1_Q6 ,  GATA1_05 ,  HEN1_02 ,  TEF_Q6 ,  CTGCAGY_UNKNOWN ,  PAX_Q6 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  MMEF2_Q6 ,  YNGTTNNNATT_UNKNOWN ,  ETS1_B ,  ELF1_Q6 ,  CEBPGAMMA_Q6 ,  STTTCRNTTT_IRF_Q6 ,  FREAC4_01 ,  FOXO4_02 ,  GGGTGGRR_PAX4_03 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-376

Cytogenetic Map:

15q21.3

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