QuickView for NEPH1 (gene)

Gene Symbol:

KIRREL1 Homo sapiens

Full name:

kirre like nephrin family adhesion molecule 1

Synonyms:

KIRREL, NEPH1, kin of IRRE-like protein 1, kin of IRRE like, kin of irregular chiasm-like protein 1, nephrin related, nephrin-like protein 1

Genomic Location:

Chr 1: 156229687-156332465

Description:

NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., ...

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NEPH1 is a member of the nephrin-like protein family, which includes NEPH2 (MIM 607761) and NEPH3 (MIM 607762). The cytoplasmic domains of these proteins interact with the C terminus of podocin (NPHS2; MIM 604766), and the genes are expressed in kidney podocytes, cells involved in ensuring size- and charge-selective ultrafiltration (Sellin et al., 2003 [PubMed 12424224]).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SMAD3_Q6 ,  SRY_01 ,  DBP_Q6 ,  TGTTTGY_HNF3_Q6 ,  TTGTTT_FOXO4_01 ,  CTTTGT_LEF1_Q2 ,  TGGTGCT_MIR29A_MIR29B_MIR29C

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-29

Cytogenetic Map:

1q23.1

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