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QuickView for NF-L (gene)


Gene Symbol:
NEFL Homo sapiens Homo sapiens
Full name:
neurofilament light
Synonyms:
CMT1F, CMT2E, NF-L, NF68, NFL, PPP1R110, neurofilament light polypeptide, light molecular weight neurofilament protein, neurofilament protein, light chain, neurofilament subunit NF-L, neurofilament triplet L protein, neurofilament, light polypeptide 68kDa, protein phosphatase 1, regulatory subunit 110
Genomic Location:
Chr 8: 24864385-24870043
Description:
Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in t...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 8
8p21.2


Transcripts Names
NM_006158
Protein Names
P07196
B9ZVN2
Q8IU72
Q16154



GO Molecular Function

structural molecule activity | guanyl-nucleotide exchange factor activity | GTPase binding | enzyme binding | Ras GTPase binding | molecular function regulator | protein domain specific binding | protein binding, bridging | identical protein binding | protein heterodimerization activity | molecular adaptor activity | protein binding | protein dimerization activity | structural constituent of cytoskeleton | Ras guanyl-nucleotide exchange factor activity | small GTPase binding | phospholipase binding | protein C-terminus binding

GO Biological Process

brain development | regulation of axon diameter | cell morphogenesis | regulation of cell projection size | guanyl-nucleotide exchange factor activity | microtubule-based transport | positive regulation of cellular component organization | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | intracellular signal transduction | regulation of cell development | intermediate filament organization | regulation of programmed cell death | hippocampus development | establishment of localization | response to hormone | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | microtubule cytoskeleton organization | cell differentiation | nervous system development | response to drug | cell part morphogenesis | positive regulation of axonogenesis | neurogenesis | generation of neurons | response to antibiotic | intracellular transport | microtubule-based process | neuromuscular process controlling balance | regulation of neuron death | cellular process | establishment of organelle localization | localization | cell projection morphogenesis | neuron development | negative regulation of apoptotic process | response to corticosterone | regulation of neuron projection development | response to inorganic substance | establishment of localization in cell | response to peptide hormone | regulation of cell differentiation | cytoskeleton-dependent intracellular transport | regeneration | regulation of cellular process | regulation of apoptotic process | organelle localization | cellular component organization | MAPK cascade | head development | response to stimulus | retrograde axonal transport | signal transduction by protein phosphorylation | response to stress | organelle transport along microtubule | intermediate filament polymerization or depolymerization | response to peptide | supramolecular fiber organization | microtubule-based movement | cellular localization | response to alcohol | neurofilament cytoskeleton organization | regulation of cellular component size | cellular component assembly | protein modification process | macromolecule modification | response to herbicide | mitochondrion transport along microtubule | molecular function regulator | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | system development | nitrogen compound metabolic process | positive regulation of neuron projection development | multicellular organism development | phosphorus metabolic process | regulation of axonogenesis | telencephalon development | intermediate filament bundle assembly | regulation of neuron differentiation | response to acrylamide | axon development | response to ketone | cellular response to stress | response to lipid | nervous system process | response to axon injury | positive regulation of cell projection organization | protein polymerization | response to corticosteroid | positive regulation of cell differentiation | mitochondrion localization | neuron projection regeneration | phosphorylation | cellular protein-containing complex assembly | response to toxic substance | protein phosphorylation | phosphate-containing compound metabolic process | cell communication | regulation of neuron apoptotic process | anterograde axonal transport | peripheral nervous system axon regeneration | limbic system development | cerebral cortex development | response to insecticide | neuron differentiation | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | response to organic substance | establishment of mitochondrion localization, microtubule-mediated | response to wounding | response to antineoplastic agent | establishment of mitochondrion localization | anatomical structure development | structural constituent of cytoskeleton | positive regulation of neurogenesis | cell projection organization | metabolic process | positive regulation of cell development | response to mineralocorticoid | negative regulation of programmed cell death | transport along microtubule | intermediate filament-based process | Ras guanyl-nucleotide exchange factor activity | neuron projection development | organic substance metabolic process | animal organ development | forebrain development | pallium development | cytoskeleton organization | axo-dendritic transport | response to arsenic-containing substance | signaling | response to organic cyclic compound | neuromuscular process | cell development | cellular protein metabolic process | anatomical structure morphogenesis | axon regeneration | regulation of nervous system development | regulation of developmental process | developmental process | axonal transport of mitochondrion | organelle organization | cellular protein modification process | response to salt | intermediate filament cytoskeleton organization | response to organonitrogen compound | central nervous system development | spinal cord development | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | regulation of cell death | response to steroid hormone | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell death | regulation of cellular component organization | axonal transport | signal transduction | response to glucocorticoid | response to sodium arsenite | macromolecule metabolic process | multicellular organismal process | neurofilament bundle assembly

GO Cellular Component

intermediate filament | supramolecular fiber | neuron projection | neurofilament | cell | distal axon | cytoplasm | intracellular organelle | intermediate filament cytoskeleton | protein-containing complex | cell projection | TSC1-TSC2 complex | plasma membrane bounded cell projection cytoplasm | cytoplasmic region | site of polarized growth | organelle | axon cytoplasm | axon | growth cone | cytosol | cytoskeleton | intracellular | myelin sheath | supramolecular complex