QuickView for NF (gene)

Gene Symbol:

NFASC Homo sapiens

Full name:

neurofascin

Synonyms:

NF, NRCAML, neurofascin, neurofascin homolog

Genomic Location:

Chr 1: 203064446-203258572

Description:

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of vo...

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This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTTTGCA_MIR527 ,  GGGACCA_MIR133A_MIR133B ,  CAGTGTT_MIR141_MIR200A ,  AAGCAAT_MIR137 ,  ACTGTGA_MIR27A_MIR27B ,  GGTGTGT_MIR329 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  GAGCTGG_MIR337 ,  TGCCTTA_MIR124A ,  ACCAAAG_MIR9 ,  CAGCAGG_MIR370 ,  GACAGGG_MIR339 ,  TCTCTCC_MIR185 ,  TTGCCAA_MIR182 ,  AAAGGAT_MIR501 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  ACAGGGT_MIR10A_MIR10B ,  ACATATC_MIR190

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-10 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-339 ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-182

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Cytogenetic Map:

1q32.1

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