QuickView for NFKBIE (gene)

Gene Symbol:

NFKBIE Homo sapiens

Full name:

NFKB inhibitor epsilon

Synonyms:

IKBE, NF-kappa-B inhibitor epsilon, I-kappa-B-epsilon, NF-kappa-BIE, ikB-E, ikB-epsilon, ikappaBepsilon, nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon

Genomic Location:

Chr 6: 44333881-44341503

Description:

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.

The protein encoded by this gene binds to components of NF-kappa-B, trapping the complex in the cytoplasm and preventing it from activating genes in the nucleus. Phosphorylation of the encoded protein targets it for destruction by the ubiquitin pathway, which activates NF-kappa-B by making it available to translocate to the nucleus.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RYTTCCTG_ETS2_B ,  TTGCWCAAY_CEBPB_02 ,  HFH4_01 ,  TGTTTGY_HNF3_Q6 ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  IK2_01 ,  SRY_02

Cytogenetic Map:

6p21.1

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