QuickView for NLRA (gene)

Gene Symbol:

CIITA Homo sapiens

Full name:

class II major histocompatibility complex transactivator

Synonyms:

C2TA, CIITAIV, MHC2TA, NLRA, MHC class II transactivator, MHC class II transactivator type I, MHC class II transactivator type III, NLR family, acid domain containing, nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing

Genomic Location:

Chr 16: 10878556-10926341

Description:

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these ge...

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This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AREB6_04 ,  IRF1_Q6 ,  IRF_Q6 ,  FOXM1_01 ,  STTTCRNTTT_IRF_Q6

Cytogenetic Map:

16p13.13

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