QuickView for NLRC5 (gene)
- Gene Symbol:
- NLRC5
Homo sapiens - Full name:
- NLR family CARD domain containing 5
- Synonyms:
- CLR16.1, NOD27, NOD4, protein NLRC5, NOD-like receptor C5, caterpiller protein 16.1, nucleotide-binding oligomerization domain protein 4, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 5, nucleotide-binding oligomerization domains 27
- Genomic Location:
- Chr 16: 55580911-55674937
- Description:
-
This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
16q13
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | ATP binding | anion binding | adenyl nucleotide binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | purine ribonucleoside triphosphate binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | RNA polymerase II regulatory region sequence-specific DNA binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | positive regulation of macromolecule biosynthetic process | response to virus | negative regulation of immune system process | negative regulation of type I interferon production | intracellular signal transduction | defense response to other organism | regulation of immune system process | negative regulation of cellular process | defense response | regulation of response to interferon-gamma | positive regulation of cellular biosynthetic process | cellular process | regulation of MHC class I biosynthetic process | negative regulation of signaling | negative regulation of innate immune response | regulation of response to cytokine stimulus | positive regulation of nitrogen compound metabolic process | regulation of immune response | regulation of cellular process | regulation of metabolic process | regulation of interferon-gamma-mediated signaling pathway | positive regulation of type I interferon-mediated signaling pathway | regulation of type I interferon production | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | response to stress | positive regulation of RNA biosynthetic process | regulation of nucleic acid-templated transcription | negative regulation of NF-kappaB transcription factor activity | positive regulation of interferon-gamma-mediated signaling pathway | positive regulation of response to cytokine stimulus | response to external biotic stimulus | regulation of signal transduction | regulation of catalytic activity | regulation of phosphorylation | regulation of gene expression | negative regulation of type I interferon-mediated signaling pathway | negative regulation of cytokine production | positive regulation of cellular metabolic process | defense response to virus | regulation of nitrogen compound metabolic process | negative regulation of DNA-binding transcription factor activity | regulation of transcription by RNA polymerase II | negative regulation of immune response | response to bacterium | cell communication | regulation of cellular metabolic process | positive regulation of signal transduction | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | regulation of innate immune response | regulation of kinase activity | regulation of DNA-binding transcription factor activity | negative regulation of response to cytokine stimulus | regulation of RNA biosynthetic process | immune response | regulation of type I interferon-mediated signaling pathway | regulation of phosphate metabolic process | positive regulation of cytokine-mediated signaling pathway | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | regulation of cytokine production | response to biotic stimulus | positive regulation of transcription, DNA-templated | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | positive regulation of metabolic process | positive regulation of response to interferon-gamma | immune system process | positive regulation of MHC class I biosynthetic process | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | microtubule organizing center | cell | cytoplasm | intracellular organelle | centrosome | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | cytosol | cytoskeleton | intracellular
