QuickView for NLRP6 (gene)
- Gene Symbol:
- NLRP6
Homo sapiens - Full name:
- NLR family pyrin domain containing 6
- Synonyms:
- AVR, CLR11.4, NALP6, NAVR, NAVR/AVR, PAN3, PYPAF5, NACHT, LRR and PYD domains-containing protein 6, NACHT, leucine rich repeat and PYD containing 6, PYRIN-containing APAF1-like protein 5, angiotensin II/vasopressin receptor, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6
- Genomic Location:
- Chr 11: 268570-275304
- Description:
-
The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Fina...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
11p15.5
GO Molecular Function
transmembrane signaling receptor activity | ribonucleotide binding | nucleotide binding | G-protein coupled receptor activity | carbohydrate derivative binding | ATP binding | anion binding | adenyl nucleotide binding | signaling receptor activity | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | peptide receptor activity | G-protein coupled peptide receptor activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | vasopressin receptor activity | heterocyclic compound binding | small molecule binding
GO Biological Process
regulation of ERK1 and ERK2 cascade | negative regulation of phosphorylation | negative regulation of MAPK cascade | negative regulation of immune system process | regulation of localization | regulation of autophagy | regulation of immune system process | negative regulation of cellular process | defense response | negative regulation of protein phosphorylation | cellular process | negative regulation of inflammatory response | negative regulation of signaling | negative regulation of cellular metabolic process | regulation of immune response | regulation of cellular process | regulation of metabolic process | negative regulation of toll-like receptor signaling pathway | G-protein coupled receptor activity | response to stimulus | response to stress | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of mucus secretion | negative regulation of ERK1 and ERK2 cascade | response to external biotic stimulus | regulation of signal transduction | negative regulation of phosphate metabolic process | regulation of toll-like receptor signaling pathway | regulation of MAPK cascade | regulation of phosphorylation | wound healing | regulation of nitrogen compound metabolic process | regulation of cellular protein metabolic process | negative regulation of immune response | response to bacterium | cell communication | regulation of cellular metabolic process | inflammatory response | regulation of protein metabolic process | regulation of protein phosphorylation | regulation of innate immune response | response to wounding | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | negative regulation of I-kappaB kinase/NF-kappaB signaling | regulation of body fluid levels | regulation of secretion | immune response | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of signal transduction | signaling | G-protein coupled peptide receptor activity | response to biotic stimulus | regulation of transport | innate immune response | vasopressin receptor activity | immune system process | negative regulation of inflammatory response to antigenic stimulus | regulation of inflammatory response | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | signal transduction | regulation of signaling | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | organelle membrane | nuclear membrane | cell | inflammasome complex | cytoplasm | intracellular organelle | protein-containing complex | endomembrane system | plasma membrane | nuclear envelope | membrane-bounded organelle | nucleus | organelle | cell periphery | cytosol | intracellular | membrane
