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Gene Symbol:
GRIN1 Homo sapiens Homo sapiens
Full name:
glutamate ionotropic receptor NMDA type subunit 1
Synonyms:
GluN1, MRD8, NMD-R1, NMDA1, NMDAR1, NR1, glutamate receptor ionotropic, NMDA 1, N-methyl-D-aspartate receptor channel, subunit zeta-1, N-methyl-D-aspartate receptor subunit NR1, glutamate [NMDA] receptor subunit zeta-1, glutamate receptor, ionotropic, N-methyl D-aspartate 1
Genomic Location:
Chr 9: 139153430-139183029
Description:
The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 9
9q34.3





GO Molecular Function

transmitter-gated ion channel activity | guanyl-nucleotide exchange factor activity | ligand-gated calcium channel activity | neurotransmitter receptor activity | GTPase binding | glycine binding | voltage-gated ion channel activity | cation binding | passive transmembrane transporter activity | neurotransmitter binding | transmembrane signaling receptor activity | carboxylic acid binding | enzyme binding | protein-containing complex binding | transmembrane transporter activity | ligand-gated ion channel activity | ion gated channel activity | signaling receptor binding | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | Ras GTPase binding | molecular function regulator | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | anion binding | amino acid binding | NMDA glutamate receptor activity | cation transmembrane transporter activity | signaling receptor activity | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | extracellular ligand-gated ion channel activity | glutamate receptor activity | ion binding | protein binding | ionotropic glutamate receptor activity | metal ion transmembrane transporter activity | voltage-gated cation channel activity | Ras guanyl-nucleotide exchange factor activity | glutamate binding | small GTPase binding | cation channel activity | calcium ion binding | glutamate-gated calcium ion channel activity | inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | drug binding | calcium channel activity | calmodulin binding | organic acid binding | metal ion binding | ion channel activity | substrate-specific channel activity | small molecule binding

GO Biological Process

transmitter-gated ion channel activity | response to extracellular stimulus | brain development | respiratory gaseous exchange | response to radiation | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | chemosensory behavior | response to nutrient levels | guanyl-nucleotide exchange factor activity | protein heterotetramerization | long-term memory | regulation of cell morphogenesis | regulation of neurogenesis | protein localization to cell periphery | regulation of cellular localization | intracellular signal transduction | regulation of synapse assembly | calcium ion transmembrane import into cytosol | positive regulation of apoptotic process | regulation of cell development | cytosolic calcium ion transport | regulation of localization | response to isoquinoline alkaloid | ligand-gated calcium channel activity | regulation of programmed cell death | establishment of localization | negative regulation of neuron death | negative regulation of cellular process | social behavior | cell differentiation | excitatory postsynaptic potential | nervous system development | response to drug | response to glycine | cellular chemical homeostasis | neurogenesis | prepulse inhibition | voltage-gated ion channel activity | generation of neurons | response to antibiotic | regulation of neuron death | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | response to morphine | localization | cellular homeostasis | positive regulation of synaptic transmission | regulation of respiratory gaseous exchange | passive transmembrane transporter activity | metal ion transport | visual learning | chemical synaptic transmission | positive regulation of reactive oxygen species metabolic process | regulation of neuronal synaptic plasticity | multicellular organismal reproductive process | learning | macromolecule localization | negative regulation of apoptotic process | regulation of proteolysis | protein localization to postsynaptic membrane | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | establishment of localization in cell | regulation of neurological system process | regulation of cell differentiation | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | xenobiotic metabolic process | regulation of cytosolic calcium ion concentration | transmembrane transporter activity | positive regulation of cellular protein metabolic process | ligand-gated ion channel activity | cellular response to organonitrogen compound | ephrin receptor signaling pathway | pons development | cellular component organization | MAPK cascade | calcium ion homeostasis | head development | conditioned taste aversion | calcium ion transport into cytosol | associative learning | response to stimulus | ion gated channel activity | metencephalon development | positive regulation of protein metabolic process | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential | positive regulation of peptidase activity | signal transduction by protein phosphorylation | cellular response to xenobiotic stimulus | response to peptide | positive regulation of cysteine-type endopeptidase activity | pons maturation | reproduction | cellular localization | divalent metal ion transport | response to alcohol | positive regulation of proteolysis | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | regulation of synapse structure or activity | modulation of chemical synaptic transmission | macromolecule modification | cell-cell signaling | molecular function regulator | cell surface receptor signaling pathway involved in cell-cell signaling | metal ion homeostasis | response to ethanol | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential | regulation of nucleic acid-templated transcription | regulation of membrane potential | response to nitrogen compound | negative regulation of neuron apoptotic process | regulation of long-term neuronal synaptic plasticity | regulation of calcium ion transport into cytosol | positive regulation of reactive oxygen species biosynthetic process | response to light stimulus | system development | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | modulation of excitatory postsynaptic potential | multicellular organism development | regulation of peptidase activity | calcium ion transmembrane transport | phosphorus metabolic process | response to amino acid | learning or memory | regulation of axonogenesis | protein complex oligomerization | regulation of catalytic activity | ion transmembrane transport | excitatory chemical synaptic transmission | telencephalon development | regulation of neuron differentiation | regulation of gene expression | regulation of postsynaptic membrane potential | protein localization to membrane | nervous system process | cellular response to peptide | synaptic signaling | NMDA glutamate receptor activity | cation transmembrane transporter activity | positive regulation of cellular metabolic process | cellular ion homeostasis | adult locomotory behavior | response to ammonium ion | regulation of synapse organization | positive regulation of cytosolic calcium ion concentration | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | regulation of transcription by RNA polymerase II | response to nutrient | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | positive regulation of hydrolase activity | second-messenger-mediated signaling | synaptic transmission, glutamatergic | cognition | olfactory behavior | locomotory behavior | sensory perception of pain | regulation of cellular protein metabolic process | hindbrain maturation | extracellular ligand-gated ion channel activity | hindbrain development | phosphorylation | positive regulation of endopeptidase activity | startle response | protein tetramerization | response to toxic substance | response to xenobiotic stimulus | protein phosphorylation | cation homeostasis | phosphate-containing compound metabolic process | protein localization to synapse | cellular cation homeostasis | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | cellular response to amyloid-beta | regulation of protein metabolic process | positive regulation of signal transduction | cellular calcium ion homeostasis | homeostatic process | suckling behavior | regulation of RNA metabolic process | positive regulation of transport | cerebral cortex development | positive regulation of molecular function | calcium-mediated signaling | multicellular organism reproduction | cation transmembrane transport | propylene metabolic process | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | response to organic substance | visual behavior | ionotropic glutamate receptor activity | metal ion transmembrane transporter activity | anatomical structure development | response to amine | regulation of dendrite morphogenesis | cell surface receptor signaling pathway | voltage-gated cation channel activity | reproductive behavior | metabolic process | regulation of RNA biosynthetic process | developmental maturation | negative regulation of programmed cell death | mating behavior | cellular protein localization | chemical homeostasis | Ras guanyl-nucleotide exchange factor activity | calcium ion transport | behavior | positive regulation of cell death | organic substance metabolic process | mating | animal organ development | positive regulation of ion transport | forebrain development | pallium development | positive regulation of programmed cell death | ion homeostasis | inorganic cation transmembrane transport | response to alkaloid | positive regulation of excitatory postsynaptic potential | regulation of reactive oxygen species biosynthetic process | cation channel activity | memory | adult behavior | regulation of dendrite development | sensory perception | olfactory learning | regulation of cell communication | transmembrane transport | glutamate-gated calcium ion channel activity | signaling | feeding behavior | inorganic cation transmembrane transporter activity | response to amyloid-beta | regulation of transcription, DNA-templated | response to organic cyclic compound | neuromuscular process | protein localization | voltage-gated channel activity | cellular protein metabolic process | protein heterooligomerization | regulation of endopeptidase activity | cation transport | cellular macromolecule localization | channel activity | glutamate receptor signaling pathway | positive regulation of calcium ion transport into cytosol | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | calcium channel activity | regulation of calcium ion transport | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | male mating behavior | cellular metal ion homeostasis | positive regulation of transcription by RNA polymerase II | central nervous system development | ion channel activity | response to anesthetic | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of synaptic plasticity | response to amphetamine | ion transport | regulation of cell projection organization | cellular metabolic process | cellular response to organic substance | regulation of cell death | negative regulation of cell death | ionotropic glutamate receptor signaling pathway | divalent inorganic cation homeostasis | substrate-specific channel activity | sexual reproduction | regulation of cellular component organization | positive regulation of calcium ion transport | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

synaptic cleft | dendritic spine | exocytic vesicle | integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | postsynaptic specialization membrane | cytoplasmic vesicle | cell | plasma membrane protein complex | distal axon | intrinsic component of membrane | synaptic membrane | terminal bouton | cytoplasm | intracellular organelle | NMDA selective glutamate receptor complex | receptor complex | endoplasmic reticulum | dendritic tree | presynapse | protein-containing complex | cell projection | secretory vesicle | postsynaptic membrane | endomembrane system | neuron spine | postsynapse | plasma membrane | postsynaptic density membrane | vesicle | transport vesicle | postsynaptic density | asymmetric synapse | integral component of plasma membrane | synaptic vesicle | extracellular region | membrane-bounded organelle | organelle | postsynaptic specialization | axon terminus | cell periphery | excitatory synapse | axon | ionotropic glutamate receptor complex | transmembrane transporter complex | neuron projection terminus | cation channel complex | ion channel complex | intracellular vesicle | cell surface | intracellular | cell junction | membrane | intrinsic component of plasma membrane