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QuickView for NM_007298 (gene)


Gene Symbol:
BRCA1 Homo sapiens Homo sapiens
Full name:
BRCA1, DNA repair associated
Synonyms:
BRCAI, BRCC1, BROVCA1, FANCS, IRIS, PNCA4, PPP1R53, PSCP, RNF53, breast cancer type 1 susceptibility protein, BRCA1/BRCA2-containing complex, subunit 1, Fanconi anemia, complementation group S, RING finger protein 53, breast and ovarian cancer susceptibility protein 1, breast cancer 1, early onset, early onset breast cancer 1, protein phosphatase 1, regulatory subunit 53
Genomic Location:
Chr 17: 38449840-38530994
Description:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). T...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q21.31





GO Molecular Function

transcription regulatory region DNA binding | RNA polymerase binding | cation binding | hormone receptor binding | enzyme binding | nucleic acid binding | signaling receptor binding | catalytic activity | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | cytoskeletal protein binding | androgen receptor binding | DNA binding | nuclear hormone receptor binding | damaged DNA binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | zinc ion binding | transcription factor binding | ubiquitin protein ligase binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | tubulin binding | steroid hormone receptor binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding | RNA binding

GO Biological Process

protein modification by small protein removal | RNA metabolic process | double-strand break repair | response to radiation | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | response to cytokine | positive regulation of cellular component organization | intracellular signal transduction | proteolysis | positive regulation of histone H3-K9 methylation | regulation of programmed cell death | cellular response to indole-3-methanol | regulation of DNA methylation | response to hormone | negative regulation of cellular process | positive regulation of developmental process | negative regulation of RNA biosynthetic process | cellular response to tumor necrosis factor | microtubule cytoskeleton organization | intrinsic apoptotic signaling pathway in response to DNA damage | response to drug | androgen receptor signaling pathway | regulation of organelle organization | hormone-mediated signaling pathway | regulation of DNA repair | microtubule-based process | positive regulation of cellular biosynthetic process | cellular process | regulation of gene expression, epigenetic | regulation of centriole replication | negative regulation of signaling | positive regulation of histone H4-K16 acetylation | regulation of histone H3-K9 methylation | negative regulation of nucleic acid-templated transcription | regulation of histone modification | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | postreplication repair | microtubule organizing center organization | dosage compensation | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | negative regulation of peptidyl-lysine acetylation | negative regulation of cellular metabolic process | regulation of transcription by RNA polymerase III | regulation of histone H3-K9 acetylation | intrinsic apoptotic signaling pathway | negative regulation of histone methylation | negative regulation of apoptotic signaling pathway | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | negative regulation of centrosome duplication | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | positive regulation of response to DNA damage stimulus | cellular lipid metabolic process | protein deubiquitination | regulation of histone H4-K16 acetylation | positive regulation of histone H4 acetylation | regulation of histone methylation | regulation of vasculature development | response to stimulus | monocarboxylic acid metabolic process | regulation of mitotic cell cycle phase transition | regulation of centrosome cycle | regulation of fatty acid biosynthetic process | genetic imprinting | chromosome segregation | positive regulation of protein metabolic process | negative regulation of centriole replication | response to stress | negative regulation of G2/M transition of mitotic cell cycle | regulation of intracellular steroid hormone receptor signaling pathway | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | regulation of protein ubiquitination | regulation of cell cycle phase transition | programmed cell death | positive regulation of vascular endothelial growth factor production | response to alcohol | cellular nitrogen compound metabolic process | double-strand break repair via nonhomologous end joining | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | steroid hormone mediated signaling pathway | cellular biosynthetic process | embryo development | DNA recombination | macromolecule modification | protein K6-linked ubiquitination | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | apoptotic process | cellular response to hormone stimulus | regulation of cell cycle G2/M phase transition | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of mitotic cell cycle phase transition | positive regulation of organelle organization | DNA damage response, signal transduction by p53 class mediator | double-strand break repair via homologous recombination | multicellular organism development | negative regulation of cell cycle G2/M phase transition | cellular response to DNA damage stimulus | lipid metabolic process | regulation of intracellular estrogen receptor signaling pathway | positive regulation of chromosome organization | DNA damage response, signal transduction resulting in transcription | positive regulation of cell cycle | signal transduction in response to DNA damage | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | positive regulation of histone H4-K20 methylation | negative regulation of histone H3-K9 methylation | cellular response to stress | response to lipid | DNA double-strand break processing | cell cycle | regulation of histone H4 acetylation | regulation of cell cycle arrest | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | small molecule metabolic process | dosage compensation by inactivation of X chromosome | regulation of transcription by RNA polymerase II | regulation of fatty acid metabolic process | negative regulation of extrinsic apoptotic signaling pathway | negative regulation of G0 to G1 transition | negative regulation of intracellular steroid hormone receptor signaling pathway | fatty acid biosynthetic process | cellular response to cytokine stimulus | positive regulation of histone H3-K9 acetylation | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | lipid biosynthetic process | regulation of apoptotic signaling pathway | signal transduction involved in cell cycle checkpoint | cellular response to drug | response to estrogen | chordate embryonic development | cell communication | regulation of cellular metabolic process | positive regulation of histone H3-K4 methylation | regulation of protein metabolic process | regulation of histone H3-K4 methylation | embryo development ending in birth or egg hatching | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of protein acetylation | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | regulation of lipid biosynthetic process | negative regulation of intracellular estrogen receptor signaling pathway | apoptotic signaling pathway | regulation of mitotic cell cycle | regulation of microtubule-based process | carboxylic acid metabolic process | protein polyubiquitination | positive regulation of cell cycle arrest | mitotic G2/M transition checkpoint | regulation of gene expression by genetic imprinting | regulation of centrosome duplication | protein metabolic process | positive regulation of protein modification process | response to organic substance | protein ubiquitination | centrosome cycle | DNA metabolic process | response to antineoplastic agent | positive regulation of peptidyl-lysine acetylation | protein autoubiquitination | anatomical structure development | mitotic cell cycle | negative regulation of lipid metabolic process | metabolic process | ubiquitin-protein transferase activity | negative regulation of histone H3-K4 methylation | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | negative regulation of cytoskeleton organization | negative regulation of mitotic cell cycle | negative regulation of histone acetylation | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | signal transduction involved in G2 DNA damage checkpoint | organic substance metabolic process | cell death | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | negative regulation of cellular protein metabolic process | gene expression | protein modification by small protein conjugation or removal | regulation of G0 to G1 transition | cytoskeleton organization | regulation of chromosome organization | cellular response to steroid hormone stimulus | fatty acid metabolic process | transcription, DNA-templated | positive regulation of cytokine production | intracellular receptor signaling pathway | negative regulation of cell cycle | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of chromosome organization | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator | response to indole-3-methanol | organic acid metabolic process | cellular protein metabolic process | regulation of cytokine production | cellular macromolecule biosynthetic process | signal transduction involved in DNA damage checkpoint | regulation of cellular ketone metabolic process | regulation of developmental process | positive regulation of DNA metabolic process | recombinational repair | developmental process | organelle organization | positive regulation of cell cycle process | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | regulation of histone acetylation | positive regulation of histone acetylation | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | regulation of vascular endothelial growth factor production | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of histone methylation | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | response to steroid hormone | regulation of organelle assembly | DNA damage checkpoint | cell cycle checkpoint | signal transduction by p53 class mediator | DNA replication | negative regulation of cell death | negative regulation of fatty acid biosynthetic process | positive regulation of angiogenesis | positive regulation of protein ubiquitination | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | response to ionizing radiation | regulation of cytoskeleton organization | negative regulation of reactive oxygen species metabolic process | negative regulation of fatty acid metabolic process | signal transduction | regulation of signaling | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

condensed nuclear chromosome | BRCA1-BARD1 complex | lateral element | chromosome | intracellular membrane-bounded organelle | catalytic complex | microtubule organizing center | nuclear ubiquitin ligase complex | cell | gamma-tubulin large complex | nuclear lumen | synaptonemal complex | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | BRCA1-A complex | nucleoplasm | plasma membrane | nuclear chromosome | ribonucleoprotein complex | transferase complex | gamma-tubulin ring complex | microtubule cytoskeleton | gamma-tubulin complex | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytoskeleton | intracellular | membrane | condensed chromosome