QuickView for NOD1 (gene)
- Gene Symbol:
- NOD1
Homo sapiens - Full name:
- nucleotide binding oligomerization domain containing 1
- Synonyms:
- CARD4, CLR7.1, NLRC1, nucleotide-binding oligomerization domain-containing protein 1, NLR family, CARD domain containing 1, caspase recruitment domain family, member 4, caspase recruitment domain-containing protein 4, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 1
- Genomic Location:
- Chr 7: 30430675-30484790
- Description:
-
This gene encodes a member of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family of proteins. The encoded protein plays a role in innate immunity by acting as a pattern-recognition receptor (PRR) that binds bacterial peptidoglycans and initiates inflammation. This protein has also been implicated in the immune response t...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
7p14.3
GO Molecular Function
enzyme activator activity | ribonucleotide binding | peptidase activator activity | nucleotide binding | CARD domain binding | carbohydrate derivative binding | molecular function regulator | protein domain specific binding | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | peptidase activator activity involved in apoptotic process | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | protein homodimerization activity | peptidoglycan binding | protein dimerization activity | glycosaminoglycan binding | cysteine-type endopeptidase regulator activity involved in apoptotic process | purine ribonucleotide binding | enzyme regulator activity | adenyl ribonucleotide binding | drug binding | cysteine-type endopeptidase activator activity involved in apoptotic process | heterocyclic compound binding | small molecule binding
GO Biological Process
positive regulation of immune response | nucleotide-binding oligomerization domain containing signaling pathway | regulation of ERK1 and ERK2 cascade | regulation of interleukin-1 beta production | regulation of cysteine-type endopeptidase activity | detection of stimulus | cellular response to muramyl dipeptide | response to cytokine | response to interleukin-1 | immune response-regulating signaling pathway | intracellular signal transduction | enzyme activator activity | positive regulation of apoptotic process | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | defense response to other organism | regulation of autophagy | regulation of immune system process | regulation of MAP kinase activity | defense response | response to drug | positive regulation of phosphate metabolic process | innate immune response-activating signal transduction | cellular process | positive regulation of nitric-oxide synthase activity | positive regulation of protein kinase activity | positive regulation of oxidoreductase activity | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | positive regulation of dendritic cell antigen processing and presentation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | peptidase activator activity | interleukin-8 production | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | positive regulation of antigen processing and presentation | cellular component organization | MAPK cascade | positive regulation of tumor necrosis factor production | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of interleukin-1 beta production | positive regulation of NIK/NF-kappaB signaling | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | response to stress | response to peptide | positive regulation of cysteine-type endopeptidase activity | response to muramyl dipeptide | programmed cell death | activation of innate immune response | positive regulation of proteolysis | immune response-activating signal transduction | regulation of macroautophagy | positive regulation of protein serine/threonine kinase activity | cellular component assembly | protein modification process | macromolecule modification | activation of protein kinase activity | molecular function regulator | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | positive regulation of monooxygenase activity | response to nitrogen compound | apoptotic process | response to external biotic stimulus | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | protein complex oligomerization | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of nitric-oxide synthase activity | regulation of gene expression | cellular response to stress | cellular response to peptide | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | interleukin-1-mediated signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | peptidase activator activity involved in apoptotic process | positive regulation of hydrolase activity | cellular response to cytokine stimulus | biosynthetic process | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | positive regulation of endopeptidase activity | protein phosphorylation | regulation of tumor necrosis factor production | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | cellular response to drug | response to bacterium | regulation of interleukin-1 production | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of interleukin-1 production | inflammatory response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of molecular function | activation of MAPK activity | cytokine production | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | positive regulation of xenophagy | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | interleukin-8 biosynthetic process | positive regulation of cell death | positive regulation of interleukin-6 production | immune response | organic substance metabolic process | cell death | positive regulation of NF-kappaB transcription factor activity | positive regulation of ERK1 and ERK2 cascade | positive regulation of programmed cell death | positive regulation of kinase activity | detection of bacterium | regulation of phosphate metabolic process | positive regulation of autophagy | positive regulation of cytokine production | positive regulation of macroautophagy | regulation of JNK cascade | positive regulation of MAPK cascade | intracellular receptor signaling pathway | defense response to Gram-positive bacterium | regulation of stress-activated MAPK cascade | regulation of cell communication | cysteine-type endopeptidase regulator activity involved in apoptotic process | regulation of antigen processing and presentation | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | positive regulation of phosphorylation | cellular protein metabolic process | enzyme regulator activity | regulation of cytokine production | regulation of endopeptidase activity | positive regulation of MAP kinase activity | response to biotic stimulus | cytokine biosynthetic process | detection of biotic stimulus | cellular response to interleukin-1 | cellular protein modification process | innate immune response | cysteine-type endopeptidase activator activity involved in apoptotic process | response to organonitrogen compound | cytokine metabolic process | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of cell death | regulation of interleukin-6 production | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
apical plasma membrane | cell | cytoplasm | apical part of cell | plasma membrane | cell periphery | basolateral plasma membrane | cytosol | intracellular | membrane
