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QuickView for NOD2;jsessionid=D2B2803848631C6706696A45CB435EAD (gene)


Gene Symbol:
NOD2 Homo sapiens Homo sapiens
Full name:
nucleotide binding oligomerization domain containing 2
Synonyms:
ACUG, BLAU, BLAUS, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, YAOS, nucleotide-binding oligomerization domain-containing protein 2, NLR family, CARD domain containing 2, NOD-like receptor C2, caspase recruitment domain family, member 15, caspase recruitment domain protein 15, caspase recruitment domain-containing protein 15, inflammatory bowel disease protein 1, nucleotide-binding oligomerization domain 2, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
Genomic Location:
Chr 16: 49288551-49324488
Description:
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 16
16q12.1





GO Molecular Function

actin binding | kinase binding | peptide binding | protein kinase binding | muramyl dipeptide binding | enzyme binding | ribonucleotide binding | nucleotide binding | CARD domain binding | carbohydrate derivative binding | protein domain specific binding | ATP binding | Hsp70 protein binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | amide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | peptidoglycan binding | glycosaminoglycan binding | Hsp90 protein binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heat shock protein binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of immune response | response to extracellular stimulus | nucleotide-binding oligomerization domain containing signaling pathway | regulation of ERK1 and ERK2 cascade | regulation of interleukin-1 beta production | positive regulation of macromolecule biosynthetic process | response to nutrient levels | detection of stimulus | cellular response to muramyl dipeptide | response to cytokine | response to interleukin-1 | regulation of B cell activation | immune response-regulating signaling pathway | intracellular signal transduction | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | defense response to other organism | establishment of localization | regulation of immune system process | negative regulation of cellular process | regulation of MAP kinase activity | epithelial structure maintenance | positive regulation of lymphocyte activation | positive regulation of epithelial cell proliferation | positive regulation of prostaglandin-E synthase activity | defense response | response to drug | positive regulation of interleukin-1 beta secretion | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of protein secretion | tissue homeostasis | positive regulation of phosphatidylinositol 3-kinase activity | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | secretion | localization | protein transport | positive regulation of immune effector process | positive regulation of protein kinase activity | macromolecule localization | negative regulation of apoptotic process | positive regulation of oxidoreductase activity | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | anatomical structure homeostasis | positive regulation of interleukin-8 production | positive regulation of dendritic cell antigen processing and presentation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | cellular response to molecule of bacterial origin | regulation of type 2 immune response | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | positive regulation of antigen processing and presentation | cellular component organization | positive regulation of dendritic cell cytokine production | MAPK cascade | positive regulation of tumor necrosis factor production | positive regulation of interleukin-17 production | regulation of peptide secretion | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | positive regulation of interleukin-1 beta production | positive regulation of NIK/NF-kappaB signaling | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | cellular response to peptidoglycan | positive regulation of protein metabolic process | negative regulation of myeloid cell apoptotic process | signal transduction by protein phosphorylation | response to stress | detection of peptidoglycan | regulation of cell proliferation | positive regulation of protein polyubiquitination | multicellular organismal homeostasis | regulation of protein ubiquitination | response to peptide | positive regulation of cell-cell adhesion | response to muramyl dipeptide | positive regulation of cell activation | activation of innate immune response | secretion by cell | positive regulation of cytokine secretion | response to molecule of bacterial origin | positive regulation of T cell activation | immune response-activating signal transduction | cellular response to organic cyclic compound | regulation of protein transport | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | regulation of peptide transport | regulation of cell adhesion | regulation of phosphatidylinositol 3-kinase activity | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | regulation of cellular response to stress | response to nitrogen compound | negative regulation of macrophage apoptotic process | regulation of macrophage apoptotic process | response to external biotic stimulus | detection of molecule of bacterial origin | nitrogen compound metabolic process | regulation of signal transduction | detection of chemical stimulus | pattern recognition receptor signaling pathway | regulation of MAPK cascade | phosphorus metabolic process | positive regulation of inflammatory response | protein complex oligomerization | maintenance of gastrointestinal epithelium | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | regulation of T cell activation | regulation of gene expression | positive regulation of secretion | organic substance transport | cellular response to stress | cellular response to peptide | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | digestive system process | regulation of lymphocyte activation | response to peptidoglycan | positive regulation of Notch signaling pathway | regulation of nitrogen compound metabolic process | regulation of Notch signaling pathway | positive regulation of JNK cascade | interleukin-1-mediated signaling pathway | peptide transport | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | positive regulation of cytokine production involved in inflammatory response | response to nutrient | detection of muramyl dipeptide | cellular response to cytokine stimulus | regulation of cytokine production involved in inflammatory response | stress-activated MAPK cascade | regulation of cellular protein metabolic process | phosphorylation | positive regulation of interleukin-1 secretion | cytokine production involved in immune response | protein phosphorylation | regulation of tumor necrosis factor production | phosphate-containing compound metabolic process | cellular response to drug | response to bacterium | regulation of lipid kinase activity | regulation of interleukin-1 production | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of interleukin-1 production | regulation of cytokine production involved in immune response | regulation of NIK/NF-kappaB signaling | regulation of protein metabolic process | positive regulation of signal transduction | defense response to bacterium | homeostatic process | positive regulation of cell proliferation | positive regulation of establishment of protein localization | regulation of protein phosphorylation | regulation of RNA metabolic process | positive regulation of B cell activation | positive regulation of transport | regulation of phospholipid metabolic process | cytokine secretion involved in immune response | nucleotide-binding oligomerization domain containing 2 signaling pathway | positive regulation of molecular function | regulation of cytokine secretion | activation of MAPK activity | cytokine production | protein-containing complex assembly | activation of immune response | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | protein metabolic process | regulation of establishment of protein localization | positive regulation of type 2 immune response | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of kinase activity | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | metabolic process | cytokine secretion | regulation of interleukin-1 beta secretion | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | negative regulation of programmed cell death | positive regulation of cytokine production involved in immune response | amide transport | regulation of secretion | regulation of myeloid cell apoptotic process | positive regulation of interleukin-6 production | regulation of protein K63-linked ubiquitination | immune response | organic substance metabolic process | regulation of cell activation | positive regulation of NF-kappaB transcription factor activity | regulation of protein secretion | positive regulation of ERK1 and ERK2 cascade | positive regulation of kinase activity | detection of bacterium | positive regulation of prostaglandin-endoperoxide synthase activity | regulation of phosphate metabolic process | regulation of dendritic cell cytokine production | positive regulation of protein K63-linked ubiquitination | establishment of protein localization | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of MAPK cascade | intracellular receptor signaling pathway | positive regulation of protein transport | regulation of stress-activated MAPK cascade | regulation of cell communication | positive regulation of interleukin-10 production | regulation of antigen processing and presentation | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | response to organic cyclic compound | protein localization | regulation of epithelial cell proliferation | negative regulation of leukocyte apoptotic process | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | positive regulation of MAP kinase activity | response to biotic stimulus | detection of biotic stimulus | cellular response to interleukin-1 | cellular protein modification process | digestion | regulation of transport | positive regulation of transcription, DNA-templated | regulation of cell-cell adhesion | innate immune response | positive regulation of nucleic acid-templated transcription | positive regulation of lipid kinase activity | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | regulation of lipid metabolic process | positive regulation of metabolic process | positive regulation of lipid metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | positive regulation of leukocyte cell-cell adhesion | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of nitric-oxide synthase biosynthetic process | positive regulation of gene expression | positive regulation of gamma-delta T cell activation | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | COP9 signalosome | cell | cytoplasm | intracellular organelle | Golgi apparatus | protein-containing complex | endomembrane system | plasma membrane | vesicle | mitochondrion | membrane-bounded organelle | nucleus | organelle | cell periphery | basolateral plasma membrane | cytosol | cell surface | cytoskeleton | intracellular | membrane