QuickView for NOS1AP (gene)

Gene Symbol:

NOS1AP Homo sapiens

Full name:

nitric oxide synthase 1 adaptor protein

Synonyms:

6330408P19Rik, CAPON, carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein, C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON), C-terminal PDZ ligand of neuronal nitric oxide synthase protein, ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain, nitric oxide synthase 1 (neuronal) adaptor protein

Genomic Location:

Chr 1: 160306205-160604864

Description:

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat pro...

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This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

SRY_01 ,  FXR_IR1_Q6 ,  TATAAA_TATA_01 ,  CAGGTG_E12_Q6 ,  TTGTTT_FOXO4_01 ,  TBP_01 ,  NFKB_Q6_01 ,  TGACATY_UNKNOWN ,  NFKB_C

Cytogenetic Map:

1q23.3

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