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QuickView for NOS2 (gene)


Gene Symbol:
NOS2 Homo sapiens Homo sapiens
Full name:
nitric oxide synthase 2
Synonyms:
HEP-NOS, INOS, NOS, NOS2A, nitric oxide synthase, inducible, NOS, type II, hepatocyte NOS, inducible NO synthase, inducible NOS, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage, peptidyl-cysteine S-nitrosylase NOS2
Genomic Location:
Chr 17: 23107919-23151682
Description:
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are l...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Canis lupus familiaris Pan troglodytes Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 17
17q11.2





GO Molecular Function

oxidoreductase activity, acting on NAD(P)H | NADP binding | cofactor binding | cation binding | carboxylic acid binding | ribonucleotide binding | FMN binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | signaling receptor binding | carbohydrate derivative binding | catalytic activity | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | anion binding | amino acid binding | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | identical protein binding | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | ion binding | organic cyclic compound binding | tetrahydrobiopterin binding | tetrapyrrole binding | protein binding | protein homodimerization activity | arginine binding | nitric-oxide synthase activity | protein dimerization activity | NADPH-hemoprotein reductase activity | heme binding | drug binding | calmodulin binding | organic acid binding | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

positive regulation of cyclase activity | positive regulation of cell killing | oxidoreductase activity, acting on NAD(P)H | peroxisome organization | response to cytokine | response to lipopolysaccharide | positive regulation of lyase activity | intracellular signal transduction | regulation of localization | lipid transport | peptidyl-amino acid modification | superoxide metabolic process | defense response to other organism | nitric oxide biosynthetic process | establishment of localization | response to hormone | defense response | response to drug | reactive oxygen species metabolic process | regulation of leukocyte mediated cytotoxicity | positive regulation of phosphate metabolic process | interleukin-6 secretion | regulation of peptide hormone secretion | intracellular transport | defense response to Gram-negative bacterium | positive regulation of cellular biosynthetic process | cellular amino acid catabolic process | cellular process | secretion | organic substance catabolic process | monocarboxylic acid transport | localization | cellular homeostasis | protein transport | protein targeting to peroxisome | positive regulation of killing of cells of other organism | anion transport | macromolecule localization | response to hypoxia | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | prostaglandin transport | establishment of localization in cell | cellular amino acid metabolic process | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | cellular response to molecule of bacterial origin | interleukin-8 production | cellular component organization | cellular response to interferon-gamma | regulation of peptide secretion | response to stimulus | acid secretion | regulation of insulin secretion | carboxylic acid catabolic process | response to stress | intracellular protein transport | cell redox homeostasis | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | circadian rhythm | cellular localization | secretion by cell | rhythmic process | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | regulation of guanylate cyclase activity | regulation of protein transport | blood circulation | negative regulation of metabolic process | protein modification process | reactive oxygen species biosynthetic process | regulation of peptide transport | cellular biosynthetic process | macromolecule modification | negative regulation of blood pressure | regulation of neurotransmitter levels | positive regulation of guanylate cyclase activity | response to external biotic stimulus | response to oxygen levels | nitrogen compound metabolic process | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen | monooxygenase activity | regulation of catalytic activity | regulation of killing of cells of other organism | regulation of hormone levels | regulation of hormone secretion | nitric oxide mediated signal transduction | regulation of gene expression | fatty acid transport | prostaglandin secretion | organic substance transport | response to lipid | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen | regulation of blood pressure | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | peptide transport | cytokine-mediated signaling pathway | organic acid transport | protein localization to organelle | second-messenger-mediated signaling | neurotransmitter metabolic process | cellular response to cytokine stimulus | interleukin-8 secretion | regulation of cytokine production involved in inflammatory response | biosynthetic process | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | organic anion transport | interleukin-6 production | establishment of protein localization to peroxisome | regulation of cyclase activity | cellular response to drug | response to bacterium | peptide secretion | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | defense response to bacterium | homeostatic process | arginine catabolic process | drug metabolic process | carboxylic acid metabolic process | positive regulation of molecular function | cytokine production | reactive nitrogen species metabolic process | protein metabolic process | regulation of establishment of protein localization | response to organic substance | regulation of cellular respiration | nitric-oxide synthase activity | peptidyl-cysteine S-nitrosylation | establishment of protein localization to organelle | cell surface receptor signaling pathway | metabolic process | lipid localization | cytokine secretion | regulation of protein catabolic process | oxidation-reduction process | cellular protein localization | amide transport | regulation of secretion | immune response | organic substance metabolic process | negative regulation of gene expression | regulation of protein secretion | protein nitrosylation | regulation of phosphate metabolic process | establishment of protein localization | response to interferon-gamma | negative regulation of protein catabolic process | negative regulation of protein metabolic process | organonitrogen compound catabolic process | neurotransmitter biosynthetic process | regulation of cell communication | arginine metabolic process | NADPH-hemoprotein reductase activity | signaling | protein localization | organic acid metabolic process | cellular protein metabolic process | carboxylic acid transport | regulation of cytokine production | cellular macromolecule localization | response to biotic stimulus | organelle organization | nitric oxide metabolic process | cellular protein modification process | mucosal immune response | regulation of transport | positive regulation of leukocyte mediated cytotoxicity | innate immune response | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | protein targeting | ion transport | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | protein secretion | oxidoreductase activity | regulation of inflammatory response | innate immune response in mucosa | response to other organism | signal transduction | regulation of signaling | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

peroxisomal matrix | intracellular membrane-bounded organelle | organelle membrane | peroxisome | cell | cytoplasm | cortical cytoskeleton | intracellular organelle | plasma membrane | vesicle | perinuclear region of cytoplasm | cytoplasmic region | cell cortex | membrane-bounded organelle | nucleus | organelle | vesicle membrane | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane