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QuickView for NOTCH3 (gene)


Gene Symbol:
NOTCH3 Homo sapiens Homo sapiens
Full name:
notch 3
Synonyms:
CADASIL, CADASIL1, CASIL, IMF2, LMNS, neurogenic locus notch homolog protein 3, Notch homolog 3
Genomic Location:
Chr 19: 15131444-15172792
Description:
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Pan troglodytes Danio rerio Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19p13.12


Transcripts Names
NM_000435
XM_005259924
Protein Names
Q9UM47
Q9Y6L8
Q9UPL3
Q9UEB3



GO Molecular Function

cadherin binding | cation binding | enzyme binding | signaling receptor activity | identical protein binding | ion binding | cell adhesion molecule binding | protein binding | calcium ion binding | metal ion binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | positive regulation of smooth muscle cell proliferation | brain development | Notch signaling pathway | DNA-templated transcription, initiation | positive regulation of macromolecule biosynthetic process | regulation of neurogenesis | regulation of cell development | negative regulation of cellular process | negative regulation of RNA biosynthetic process | cell differentiation | glomerulus development | nervous system development | neurogenesis | generation of neurons | blood vessel morphogenesis | positive regulation of cellular biosynthetic process | cellular process | negative regulation of signaling | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of cell differentiation | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | urogenital system development | head development | response to stimulus | vasculature development | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | cardiovascular system development | cellular nitrogen compound metabolic process | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | kidney development | positive regulation of transcription of Notch receptor target | blood vessel development | neuron fate commitment | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | glomerulus vasculature development | artery development | regulation of neuron differentiation | regulation of gene expression | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of Notch signaling pathway | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | angiogenesis | glomerulus morphogenesis | cell communication | regulation of cellular metabolic process | glomerular capillary formation | positive regulation of cell proliferation | regulation of RNA metabolic process | renal system development | nephron development | neuron differentiation | artery morphogenesis | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | negative regulation of neuron differentiation | gene expression | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | anatomical structure formation involved in morphogenesis | regulation of cell communication | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | developmental process | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | negative regulation of Notch signaling pathway | cellular metabolic process | regulation of smooth muscle cell proliferation | negative regulation of cell development | circulatory system development | negative regulation of cell differentiation | signal transduction | regulation of signaling | positive regulation of gene expression | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | organelle membrane | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | actin cytoskeleton | receptor complex | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | plasma membrane | Golgi membrane | extracellular region | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane