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QuickView for NOX1 (gene)


Gene Symbol:
NOX1 Homo sapiens Homo sapiens
Full name:
NADPH oxidase 1
Synonyms:
GP91-2, MOX1, NOH-1, NOH1, NADPH oxidase 1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NADPH oxidase homolog-1, mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating), mitogenic oxidase 1
Genomic Location:
Chr X: 99984969-100015990
Description:
This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr X
Xq22.1





GO Molecular Function

oxidoreductase activity, acting on NAD(P)H | NADP binding | cofactor binding | GTPase binding | Rho GTPase binding | voltage-gated ion channel activity | cation binding | passive transmembrane transporter activity | superoxide-generating NADPH oxidase activity | enzyme binding | transmembrane transporter activity | nucleotide binding | ion gated channel activity | coenzyme binding | Ras GTPase binding | catalytic activity | transporter activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | protein binding | Rac GTPase binding | small GTPase binding | voltage-gated channel activity | channel activity | metal ion binding | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding

GO Biological Process

response to acidic pH | positive regulation of smooth muscle cell proliferation | cellular response to increased oxygen levels | positive regulation of macromolecule biosynthetic process | oxidoreductase activity, acting on NAD(P)H | regulation of systemic arterial blood pressure by hormone | extracellular structure organization | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | cell motility | positive regulation of apoptotic process | regulation of integrin biosynthetic process | regulation of localization | regulation of programmed cell death | superoxide metabolic process | establishment of localization | cellular response to hyperoxia | positive regulation of intrinsic apoptotic signaling pathway | defense response | reactive oxygen species metabolic process | cellular chemical homeostasis | positive regulation of phosphate metabolic process | voltage-gated ion channel activity | blood vessel morphogenesis | cellular process | localization | cellular homeostasis | passive transmembrane transporter activity | nucleotide metabolic process | superoxide-generating NADPH oxidase activity | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | transmembrane transporter activity | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | cellular response to acidic pH | cellular aromatic compound metabolic process | cellular component organization | superoxide anion generation | regulation of systemic arterial blood pressure mediated by a chemical signal | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | ion gated channel activity | vasculature development | positive regulation of protein metabolic process | response to stress | regulation of cell proliferation | tube morphogenesis | positive regulation of vascular endothelial growth factor production | cardiovascular system development | cellular nitrogen compound metabolic process | extracellular matrix organization | blood circulation | cofactor metabolic process | positive regulation of response to oxidative stress | response to pH | blood vessel development | regulation of cellular response to stress | locomotion | cellular stress response to acidic pH | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | cell migration | antibiotic metabolic process | regulation of MAPK cascade | phosphorus metabolic process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | ion transmembrane transport | cellular response to pH | cellular response to stress | regulation of blood pressure | regulation of systemic arterial blood pressure by renin-angiotensin | organophosphate metabolic process | regulation of systemic arterial blood pressure | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | cellular ion homeostasis | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | small molecule metabolic process | positive regulation of intracellular signal transduction | ion transmembrane transporter activity | nucleobase-containing small molecule metabolic process | regulation of cellular protein metabolic process | oxygen metabolic process | angiogenesis | response to hyperoxia | regulation of apoptotic signaling pathway | cation homeostasis | phosphate-containing compound metabolic process | cellular cation homeostasis | endocrine process | cell communication | regulation of cellular metabolic process | regulation of intracellular pH | inflammatory response | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of cell proliferation | regulation of protein phosphorylation | positive regulation of oxidative stress-induced cell death | drug metabolic process | positive regulation of protein modification process | regulation of pH | regulation of intracellular signal transduction | anatomical structure development | metabolic process | oxidation-reduction process | chemical homeostasis | positive regulation of cell death | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of programmed cell death | ion homeostasis | regulation of phosphate metabolic process | regulation of ion transmembrane transport | positive regulation of cytokine production | regulation of cellular pH | regulation of JNK cascade | positive regulation of MAPK cascade | respiratory burst | anatomical structure formation involved in morphogenesis | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | intracellular pH elevation | regulation of stress-activated MAPK cascade | regulation of cell communication | transmembrane transport | signaling | cellular monovalent inorganic cation homeostasis | positive regulation of phosphorylation | voltage-gated channel activity | regulation of cytokine production | anatomical structure morphogenesis | channel activity | NADP metabolic process | regulation of ion transport | developmental process | nicotinamide nucleotide metabolic process | tube development | regulation of transport | heterocycle metabolic process | regulation of vascular endothelial growth factor production | hydrogen peroxide metabolic process | positive regulation of metabolic process | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor | ion transport | cellular metabolic process | regulation of cell death | regulation of smooth muscle cell proliferation | oxidoreductase activity | circulatory system development | regulation of cellular component organization | positive regulation of integrin biosynthetic process | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | catalytic complex | cell projection membrane | NADPH oxidase complex | cytoplasmic vesicle | cell | oxidoreductase complex | plasma membrane protein complex | intrinsic component of membrane | cytoplasm | intracellular organelle | protein-containing complex | cell projection | endomembrane system | plasma membrane | vesicle | invadopodium membrane | integral component of plasma membrane | endosome | membrane-bounded organelle | organelle | cell periphery | early endosome | invadopodium | intracellular vesicle | intracellular | cell junction | membrane | intrinsic component of plasma membrane