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QuickView for NPAS2;jsessionid=402B4933CA5B757CAE76F7EB9CBFFBCE (gene)


Gene Symbol:
NPAS2 Homo sapiens Homo sapiens
Full name:
neuronal PAS domain protein 2
Synonyms:
MOP4, PASD4, bHLHe9, neuronal PAS domain-containing protein 2, PAS domain-containing protein 4, basic-helix-loop-helix-PAS protein MOP4, class E basic helix-loop-helix protein 9, member of PAS protein 4, member of PAS superfamily 4, neuronal PAS2
Genomic Location:
Chr 2: 100803045-100979719
Description:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
TGGAAA_NFAT_Q4_01 TTTGCAC_MIR19A_MIR19B HNF1_01 TAL1ALPHAE47_01 RYTTCCTG_ETS2_B HOXA4_Q2 SRF_Q6 XBP1_01 WGTTNNNNNAAA_UNKNOWN FXR_IR1_Q6
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2q11.2





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | cation binding | nucleic acid binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | Hsp90 protein binding | heat shock protein binding | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | positive regulation of macromolecule biosynthetic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | nervous system development | regulation of DNA repair | positive regulation of cellular biosynthetic process | cellular process | circadian regulation of gene expression | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of metabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | positive regulation of response to DNA damage stimulus | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | circadian rhythm | rhythmic process | cellular nitrogen compound metabolic process | positive regulation of RNA biosynthetic process | cellular biosynthetic process | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | system development | nitrogen compound metabolic process | multicellular organism development | cellular response to DNA damage stimulus | regulation of gene expression | cellular response to stress | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | regulation of cellular metabolic process | regulation of RNA metabolic process | DNA-binding transcription factor activity | anatomical structure development | metabolic process | regulation of RNA biosynthetic process | regulation of response to DNA damage stimulus | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | regulation of transcription, DNA-templated | cellular macromolecule biosynthetic process | positive regulation of DNA metabolic process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | regulation of lipid metabolic process | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | negative regulation of cell death | response to redox state | positive regulation of gene expression | positive regulation of DNA repair | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular