QuickView for NPM1 (gene)
- Gene Symbol:
- NPM1
Homo sapiens - Full name:
- nucleophosmin 1
- Synonyms:
- B23, NPM, nucleophosmin, nucleolar protein NO38, nucleophosmin (nucleolar phosphoprotein B23, numatrin), nucleophosmin/nucleoplasmin family, member 1, testicular tissue protein Li 128
- Genomic Location:
- Chr 5: 170747403-170770493
- Description:
-
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known t...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites: -
USF_Q6 , ARNT_01 , MYCMAX_03 , CACGTG_MYC_Q2 , CCAGGTT_MIR490 , MAX_01 , MYCMAX_B , RFX1_01 , TATCTGG_MIR488 , MYCMAX_02
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
5q35.1
| Transcripts Names |
|---|
| NM_001037738 |
| NM_002520 |
| NM_199185 |
| NM_001355010 |
| NM_001355009 |
| NR_149149 |
| NM_001355007 |
| NM_001355006 |
GO Molecular Function
ribosomal small subunit binding | kinase binding | protein kinase regulator activity | NF-kappaB binding | transcription regulatory region DNA binding | core promoter binding | kinase regulator activity | protein kinase inhibitor activity | protein kinase binding | enzyme binding | nucleic acid binding | protein-containing complex binding | enzyme inhibitor activity | unfolded protein binding | molecular function regulator | chromatin binding | ribonucleoprotein complex binding | DNA binding | identical protein binding | protein heterodimerization activity | organic cyclic compound binding | transcription coactivator activity | protein binding | protein homodimerization activity | transcription factor binding | kinase inhibitor activity | activating transcription factor binding | protein dimerization activity | histone binding | ribosomal large subunit binding | enzyme regulator activity | transcription coregulator activity | heterocyclic compound binding | Tat protein binding | RNA binding
GO Biological Process
negative regulation of phosphorylation | response to radiation | regulation of cell cycle process | regulation of endoribonuclease activity | positive regulation of macromolecule biosynthetic process | ncRNA export from nucleus | nuclear export | protein kinase regulator activity | positive regulation of DNA-binding transcription factor activity | nucleosome organization | regulation of programmed cell death | establishment of localization | negative regulation of cellular process | negative regulation of kinase activity | microtubule cytoskeleton organization | negative regulation of protein phosphorylation | regulation of organelle organization | rRNA export from nucleus | intracellular transport | microtubule-based process | positive regulation of cellular biosynthetic process | cellular process | regulation of centriole replication | establishment of organelle localization | localization | chromatin organization | protein transport | CENP-A containing chromatin organization | kinase regulator activity | protein kinase inhibitor activity | macromolecule localization | negative regulation of apoptotic process | microtubule organizing center organization | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | ribosome biogenesis | establishment of localization in cell | negative regulation of cellular metabolic process | interspecies interaction between organisms | ribosomal large subunit biogenesis | regulation of mRNA stability | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | organelle localization | negative regulation of centrosome duplication | positive regulation of cell cycle phase transition | regulation of endodeoxyribonuclease activity | organic cyclic compound metabolic process | positive regulation of translation | positive regulation of cellular protein metabolic process | cellular aromatic compound metabolic process | cellular component organization | protein export from nucleus | response to UV | regulation of translational initiation | CENP-A containing nucleosome assembly | response to stimulus | enzyme inhibitor activity | rRNA transport | regulation of centrosome cycle | positive regulation of protein metabolic process | cellular response to light stimulus | response to stress | intracellular protein transport | negative regulation of protein kinase activity | posttranscriptional regulation of gene expression | regulation of cell proliferation | regulation of cell cycle phase transition | protein-DNA complex assembly | cellular localization | cellular nitrogen compound metabolic process | ribosomal small subunit export from nucleus | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | ribosome localization | molecular function regulator | DNA repair | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | response to nitrogen compound | organelle assembly | regulation of cell cycle G2/M phase transition | response to light stimulus | nitrogen compound metabolic process | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | negative regulation of protein kinase activity by regulation of protein phosphorylation | ribonucleoprotein complex localization | response to dsRNA | cellular response to DNA damage stimulus | protein complex oligomerization | regulation of catalytic activity | regulation of phosphorylation | ATP-dependent chromatin remodeling | positive regulation of cell cycle | regulation of gene expression | centromere complex assembly | organic substance transport | cellular response to stress | cell cycle | positive regulation of cellular metabolic process | cellular response to radiation | DNA replication-independent nucleosome assembly | regulation of mRNA stability involved in cellular response to UV | regulation of nitrogen compound metabolic process | peptide transport | ribosomal subunit export from nucleus | regulation of RNA stability | regulation of transcription by RNA polymerase II | positive regulation of cell cycle G2/M phase transition | ribosome assembly | regulation of cellular protein metabolic process | RNA export from nucleus | cellular protein-containing complex assembly | establishment of RNA localization | cellular response to UV | cell communication | regulation of cellular metabolic process | chromatin remodeling | regulation of protein kinase activity | protein-containing complex localization | regulation of protein metabolic process | cellular response to dsRNA | positive regulation of cell proliferation | regulation of protein phosphorylation | transcription coactivator activity | regulation of RNA metabolic process | viral process | ribosomal large subunit export from nucleus | cell aging | regulation of microtubule-based process | positive regulation of molecular function | regulation of centrosome duplication | protein-containing complex assembly | response to organic substance | centrosome cycle | kinase inhibitor activity | regulation of kinase activity | DNA metabolic process | regulation of DNA-binding transcription factor activity | chromatin assembly or disassembly | nucleobase-containing compound transport | metabolic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | negative regulation of cytoskeleton organization | cellular protein localization | amide transport | nucleobase-containing compound metabolic process | organic substance metabolic process | nuclear transport | regulation of mRNA catabolic process | negative regulation of cellular protein metabolic process | positive regulation of NF-kappaB transcription factor activity | ribonucleoprotein complex assembly | regulation of phosphate metabolic process | DNA packaging | cytoskeleton organization | regulation of ribonuclease activity | establishment of protein localization | RNA transport | chromatin assembly | negative regulation of cell cycle | negative regulation of protein metabolic process | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | histone exchange | protein localization | enzyme regulator activity | cellular macromolecule localization | nucleocytoplasmic transport | developmental process | organelle organization | DNA replication-independent nucleosome organization | positive regulation of cell cycle process | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | positive regulation of nucleic acid-templated transcription | DNA conformation change | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | ribosomal small subunit biogenesis | nucleosome assembly | positive regulation of metabolic process | chromosome organization | ribonucleoprotein complex biogenesis | chromatin remodeling at centromere | cellular metabolic process | negative regulation of cell cycle process | cellular response to organic substance | regulation of cell death | regulation of organelle assembly | regulation of translation | negative regulation of cell death | regulation of eIF2 alpha phosphorylation by dsRNA | aging | RNA localization | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | signal transduction | positive regulation of gene expression | macromolecule metabolic process | regulation of phosphorus metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | adherens junction | microtubule organizing center | focal adhesion | cell | nuclear lumen | spindle pole centrosome | nucleolus | cytoplasm | spindle | cell-substrate junction | intracellular organelle | centrosome | protein-containing complex | protein-DNA complex | nucleoplasm | ribonucleoprotein complex | microtubule cytoskeleton | spindle pole | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cell-substrate adherens junction | cytosol | cytoskeleton | intracellular | cell junction | membrane
