QuickView for NPPB (gene)

Gene Symbol:

NPPB Homo sapiens

Full name:

natriuretic peptide B

Synonyms:

BNP, natriuretic peptides B, brain type natriuretic peptide, gamma-brain natriuretic peptide, natriuretic peptide precursor B, natriuretic protein

Genomic Location:

Chr 1: 11840108-11841579

Description:

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone s...

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This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

FREAC7_01 ,  TGANTCA_AP1_C ,  NRSF_01 ,  TEF1_Q6 ,  TTCYRGAA_UNKNOWN ,  CAGNWMCNNNGAC_UNKNOWN ,  HSF_Q6 ,  GATA4_Q3 ,  TGATTTRY_GFI1_01

Cytogenetic Map:

1p36.22

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