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QuickView for NQO1 (gene)


Gene Symbol:
NQO1 Homo sapiens Homo sapiens
Full name:
NAD(P)H quinone dehydrogenase 1
Synonyms:
DHQU, DIA4, DTD, NMOR1, NMORI, QR1, NAD(P)H dehydrogenase [quinone] 1, DT-diaphorase, NAD(P)H dehydrogenase, quinone 1, NAD(P)H:Quinone acceptor oxidoreductase type 1, NAD(P)H:menadione oxidoreductase 1, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxireductase, azoreductase, diaphorase (NADH/NADPH) (cytochrome b-5 reductase), diaphorase-4, dioxin-inducible 1, menadione reductase, phylloquinone reductase, quinone reductase 1
Genomic Location:
Chr 16: 68300805-68318034
Description:
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this ge...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Pan troglodytes Bos taurus Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Cytogenetic Map:
chr 16
16q22.1





GO Molecular Function

oxidoreductase activity, acting on NAD(P)H | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | antioxidant activity | cytochrome-b5 reductase activity, acting on NAD(P)H | nucleic acid binding | catalytic activity | electron transfer activity | identical protein binding | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | organic cyclic compound binding | protein binding | superoxide dismutase activity | NAD(P)H dehydrogenase (quinone) activity | heterocyclic compound binding | oxidoreductase activity | RNA binding

GO Biological Process

response to extracellular stimulus | oxidoreductase activity, acting on NAD(P)H | response to nutrient levels | positive regulation of apoptotic process | regulation of programmed cell death | superoxide metabolic process | nitric oxide biosynthetic process | response to hormone | negative regulation of cellular process | response to metal ion | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | response to drug | reactive oxygen species metabolic process | generation of precursor metabolites and energy | response to antibiotic | regulation of neuron death | cellular process | cellular detoxification | antioxidant activity | chemical synaptic transmission | response to hydrogen sulfide | response to estradiol | negative regulation of apoptotic process | response to inorganic substance | cytochrome-b5 reductase activity, acting on NAD(P)H | response to hydrogen peroxide | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | xenobiotic metabolic process | cellular response to metal ion | response to stimulus | cellular response to xenobiotic stimulus | response to stress | cellular nitrogen compound biosynthetic process | electron transport chain | cellular response to inorganic substance | response to alcohol | cellular nitrogen compound metabolic process | cellular response to toxic substance | reactive oxygen species biosynthetic process | cellular biosynthetic process | cell-cell signaling | response to ethanol | regulation of neurotransmitter levels | response to nitrogen compound | removal of superoxide radicals | nitrogen compound metabolic process | cellular response to antibiotic | negative regulation of catalytic activity | regulation of catalytic activity | cellular response to oxidative stress | electron transfer activity | regulation of cellular amino acid metabolic process | cellular response to stress | response to lipid | synaptic signaling | response to superoxide | regulation of nitrogen compound metabolic process | response to nutrient | response to oxidative stress | response to oxygen radical | neurotransmitter metabolic process | biosynthetic process | oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor | positive regulation of neuron death | response to toxic substance | response to xenobiotic stimulus | cellular response to drug | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | drug metabolic process | reactive nitrogen species metabolic process | response to organic substance | positive regulation of neuron apoptotic process | metabolic process | cellular oxidant detoxification | oxidation-reduction process | negative regulation of programmed cell death | cellular response to hydrogen peroxide | positive regulation of cell death | cellular response to reactive oxygen species | response to reactive oxygen species | positive regulation of programmed cell death | superoxide dismutase activity | neurotransmitter biosynthetic process | negative regulation of molecular function | signaling | response to organic cyclic compound | regulation of cellular ketone metabolic process | developmental process | NAD(P)H dehydrogenase (quinone) activity | nitric oxide metabolic process | synaptic transmission, cholinergic | detoxification | response to electrical stimulus | cellular response to superoxide | cellular metabolic process | regulation of cell death | oxidoreductase activity | negative regulation of cell death | aging

GO Cellular Component

dendrite | neuron projection | somatodendritic compartment | cell body | cell | neuronal cell body | cytoplasm | dendritic tree | cell projection | cytosol | intracellular