QuickView for NQO2 (gene)
- Gene Symbol:
- NQO2
Homo sapiens - Full name:
- N-ribosyldihydronicotinamide:quinone reductase 2
- Synonyms:
- DHQV, DIA6, NMOR2, QR2, ribosyldihydronicotinamide dehydrogenase [quinone], NAD(P)H dehydrogenase, quinone 2, NAD(P)H menadione oxidoreductase-1, dioxin-inducible-2, NAD(P)H quinone dehydrogenase 2, NRH:quinone oxidoreductase 2, quinone reductase 2, ribosyldihydronicotinamide dehydrogenase
- Genomic Location:
- Chr 6: 2945066-2964993
- Description:
-
This gene encodes a member of the thioredoxin family of enzymes. It is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone substrates and uses dihydronicotinamide riboside as a reducing coenzyme. Mutations in this gene have been associated with neurodegenerative diseases and several cancers. Alte...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
6p25.2
GO Molecular Function
oxidoreductase activity, acting on NAD(P)H | melatonin binding | cofactor binding | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | cation binding | dihydronicotinamide riboside quinone reductase activity | resveratrol binding | nucleotide binding | flavin adenine dinucleotide binding | coenzyme binding | catalytic activity | anion binding | electron transfer activity | chloride ion binding | amide binding | identical protein binding | ion binding | organic cyclic compound binding | hormone binding | protein binding | protein homodimerization activity | zinc ion binding | FAD binding | protein dimerization activity | oxidoreductase activity, acting on other nitrogenous compounds as donors | transition metal ion binding | drug binding | NAD(P)H dehydrogenase (quinone) activity | metal ion binding | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
oxidoreductase activity, acting on NAD(P)H | oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor | generation of precursor metabolites and energy | cellular process | dihydronicotinamide riboside quinone reductase activity | xenobiotic metabolic process | response to stimulus | cellular response to xenobiotic stimulus | electron transport chain | electron transfer activity | response to xenobiotic stimulus | metabolic process | oxidation-reduction process | oxidoreductase activity, acting on other nitrogenous compounds as donors | NAD(P)H dehydrogenase (quinone) activity | cellular metabolic process | oxidoreductase activity
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | membrane-enclosed lumen | cytosol | intracellular
