QuickView for NR1H4 (gene)
- Gene Symbol:
- NR1H4
Homo sapiens - Full name:
- nuclear receptor subfamily 1 group H member 4
- Synonyms:
- BAR, FXR, HRR-1, HRR1, PFIC5, RIP14, bile acid receptor, RXR-interacting protein 14, farnesoid X nuclear receptor, farnesoid X-activated receptor, farnesol receptor HRR-1, retinoid X receptor-interacting protein 14
- Genomic Location:
- Chr 12: 99391810-99481774
- Description:
-
This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced t...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Danio rerio , Pan troglodytes , Bos taurus , Canis lupus familiaris
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12q23.1
GO Molecular Function
sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | retinoic acid receptor binding | nuclear receptor activity | cation binding | hormone receptor binding | bile acid receptor activity | transcription factor activity, direct ligand regulated sequence-specific DNA binding | transcription factor activity, RNA polymerase II transcription factor binding | bile acid binding | carboxylic acid binding | nucleic acid binding | chenodeoxycholic acid binding | lipid binding | signaling receptor binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | steroid hormone receptor activity | anion binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | signaling receptor activity | sequence-specific double-stranded DNA binding | transcription corepressor activity | nuclear hormone receptor binding | ion binding | organic cyclic compound binding | retinoid X receptor binding | transcription coactivator activity | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | zinc ion binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | nuclear receptor transcription coactivator activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transition metal ion binding | nuclear receptor binding | steroid binding | transcription coregulator activity | organic acid binding | metal ion binding | heterocyclic compound binding | thyroid hormone receptor activity | small molecule binding
GO Biological Process
positive regulation of immune response | RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | Notch signaling pathway | DNA-templated transcription, initiation | positive regulation of insulin secretion involved in cellular response to glucose stimulus | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | response to nutrient levels | immune response-regulating signaling pathway | response to lipopolysaccharide | regulation of cellular localization | negative regulation of peptide secretion | regulation of localization | lipid transport | regulation of programmed cell death | histone arginine methylation | peptidyl-amino acid modification | defense response to other organism | establishment of localization | regulation of immune system process | response to hormone | positive regulation of glutamate metabolic process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | defense response | cellular response to extracellular stimulus | cellular chemical homeostasis | glucose homeostasis | positive regulation of phosphate metabolic process | negative regulation of protein secretion | regulation of peptide hormone secretion | positive regulation of protein secretion | hormone-mediated signaling pathway | innate immune response-activating signal transduction | positive regulation of cellular biosynthetic process | cellular process | secretion | nitrogen catabolite regulation of transcription from RNA polymerase II promoter | toll-like receptor signaling pathway | negative regulation of inflammatory response | nuclear receptor activity | monocarboxylic acid transport | regulation of glucose import | localization | cellular homeostasis | chromatin organization | protein transport | negative regulation of signaling | bile acid receptor activity | anion homeostasis | anion transport | negative regulation of tumor necrosis factor-mediated signaling pathway | transcription factor activity, direct ligand regulated sequence-specific DNA binding | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of response to cytokine stimulus | negative regulation of apoptotic process | negative regulation of lipid biosynthetic process | negative regulation of secretion | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | cell junction assembly | regulation of bile acid biosynthetic process | regulation of immune response | regulation of cellular process | negative regulation of interleukin-1 production | regulation of apoptotic process | positive regulation of insulin receptor signaling pathway | cellular response to lipid | regulation of metabolic process | negative regulation of cytokine secretion | cellular response to molecule of bacterial origin | negative regulation of tumor necrosis factor production | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | interleukin-17 secretion | cellular component organization | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | cellular triglyceride homeostasis | monocarboxylic acid metabolic process | regulation of adipose tissue development | positive regulation of innate immune response | nitrogen catabolite activation of transcription from RNA polymerase II promoter | regulation of insulin secretion | positive regulation of immune system process | response to stress | negative regulation of tumor necrosis factor superfamily cytokine production | cellular nitrogen compound biosynthetic process | positive regulation of lipid biosynthetic process | sterol homeostasis | negative regulation of interferon-gamma production | positive regulation of glucose import | cholesterol homeostasis | negative regulation of monocyte chemotactic protein-1 production | activation of innate immune response | secretion by cell | organic hydroxy compound transport | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | positive regulation of hormone secretion | immune response-activating signal transduction | bile acid signaling pathway | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | steroid hormone receptor activity | protein modification process | steroid hormone mediated signaling pathway | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | macromolecule modification | regulation of steroid metabolic process | regulation of glutamate metabolic process | regulation of glutamine family amino acid metabolic process | regulation of nucleic acid-templated transcription | positive regulation of peptide secretion | negative regulation of NF-kappaB transcription factor activity | organic hydroxy compound metabolic process | response to nitrogen compound | cellular response to hormone stimulus | response to external biotic stimulus | negative regulation of tumor necrosis factor secretion | cellular response to nutrient levels | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | negative regulation of secretion by cell | negative regulation of interleukin-6 production | multicellular organism development | histone methylation | response to fatty acid | regulation of insulin secretion involved in cellular response to glucose stimulus | lipid metabolic process | regulation of hormone levels | regulation of hormone secretion | positive regulation of glucose import in response to insulin stimulus | regulation of gene expression | regulation of phospholipid biosynthetic process | positive regulation of secretion | negative regulation of chemokine production | methylation | regulation of cellular amino acid metabolic process | organic substance transport | response to lipid | regulation of glucose import in response to insulin stimulus | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of adipose tissue development | regulation of nitrogen compound metabolic process | small molecule metabolic process | peptide transport | negative regulation of DNA-binding transcription factor activity | transcription corepressor activity | regulation of transcription by RNA polymerase II | response to nutrient | organic acid transport | positive regulation of phosphatidic acid biosynthetic process | interleukin-17 production | regulation of cholesterol metabolic process | positive regulation of glucose transmembrane transport | biosynthetic process | aromatic compound biosynthetic process | organic anion transport | regulation of bile acid metabolic process | triglyceride homeostasis | regulation of tumor necrosis factor production | positive regulation of cellular response to insulin stimulus | response to bacterium | regulation of interleukin-1 production | peptidyl-arginine methylation | peptide secretion | cell communication | regulation of cellular metabolic process | histone H3-R17 methylation | inflammatory response | regulation of tumor necrosis factor-mediated signaling pathway | positive regulation of signal transduction | positive regulation of nitrogen utilization | negative regulation of interleukin-2 production | defense response to bacterium | homeostatic process | nitrogen catabolite activation of transcription | positive regulation of establishment of protein localization | regulation of cytokine-mediated signaling pathway | transcription coactivator activity | regulation of RNA metabolic process | positive regulation of transport | regulation of phospholipid metabolic process | positive regulation of peptide hormone secretion | regulation of lipid biosynthetic process | cellular response to fatty acid | carboxylic acid metabolic process | bile acid metabolic process | regulation of cytokine secretion | transcriptional activator activity, RNA polymerase II transcription factor binding | regulation of nitrogen utilization | cytokine production | toll-like receptor 9 signaling pathway | activation of immune response | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | cellular response to nutrient | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | regulation of innate immune response | positive regulation of insulin secretion | fatty acid homeostasis | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | anatomical structure development | cell surface receptor signaling pathway | negative regulation of response to cytokine stimulus | negative regulation of lipid metabolic process | metabolic process | lipid localization | cytokine secretion | negative regulation of I-kappaB kinase/NF-kappaB signaling | cell-cell junction assembly | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | nuclear receptor transcription coactivator activity | negative regulation of programmed cell death | amide transport | bile acid and bile salt transport | chemical homeostasis | regulation of secretion | toll-like receptor 4 signaling pathway | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of glucose transmembrane transport | regulation of insulin receptor signaling pathway | gene expression | regulation of protein secretion | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | ion homeostasis | regulation of cellular response to insulin stimulus | regulation of tumor necrosis factor secretion | regulation of phosphate metabolic process | intracellular bile acid receptor signaling pathway | cellular response to steroid hormone stimulus | negative regulation of bile acid biosynthetic process | establishment of protein localization | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | intracellular receptor signaling pathway | positive regulation of protein transport | positive regulation of ammonia assimilation cycle | steroid metabolic process | regulation of cell communication | negative regulation of molecular function | negative regulation of signal transduction | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | protein localization | organic acid metabolic process | cellular protein metabolic process | carboxylic acid transport | regulation of cytokine production | cellular macromolecule biosynthetic process | protein methylation | response to biotic stimulus | regulation of cellular ketone metabolic process | regulation of developmental process | developmental process | organelle organization | negative regulation of steroid metabolic process | cellular protein modification process | acylglycerol homeostasis | regulation of monocyte chemotactic protein-1 production | positive regulation of phospholipid biosynthetic process | regulation of chemokine production | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | innate immune response | regulation of urea metabolic process | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | negative regulation of interferon-gamma secretion | transcription coregulator activity | regulation of low-density lipoprotein particle clearance | positive regulation of transcription by RNA polymerase II | negative regulation of cytokine-mediated signaling pathway | heterocycle metabolic process | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | positive regulation of lipid metabolic process | ion transport | regulation of interferon-gamma production | immune system process | cellular metabolic process | cellular response to organic substance | regulation of protein localization | regulation of cell death | protein secretion | response to steroid hormone | negative regulation of cell death | regulation of interleukin-6 production | regulation of inflammatory response | carbohydrate homeostasis | thyroid hormone receptor activity | lipid homeostasis | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of steroid biosynthetic process | response to other organism | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process
GO Cellular Component
nuclear euchromatin | nuclear transcription factor complex | chromosome | intracellular membrane-bounded organelle | RNA polymerase II transcription factor complex | cell | nuclear lumen | transcription factor complex | intracellular organelle | euchromatin | protein-containing complex | nucleoplasm | chromatin | nuclear chromosome | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular
