QuickView for NR2B (gene)

Gene Symbol:

GRIN2B Homo sapiens

Full name:

glutamate ionotropic receptor NMDA type subunit 2B

Synonyms:

EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, NR3, hNR3, glutamate receptor ionotropic, NMDA 2B, N-methyl D-aspartate receptor subtype 2B, N-methyl-D-aspartate receptor subunit 3, glutamate [NMDA] receptor subunit epsilon-2, glutamate receptor subunit epsilon-2, glutamate receptor, ionotropic, N-methyl D-aspartate 2B

Genomic Location:

Chr 12: 13605411-14024319

Description:

This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission i...

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This gene encodes a member of the N-methyl-D-aspartate (NMDA) receptor family within the ionotropic glutamate receptor superfamily. The encoded protein is a subunit of the NMDA receptor ion channel which acts as an agonist binding site for glutamate. The NMDA receptors mediate a slow calcium-permeable component of excitatory synaptic transmission in the central nervous system. The NMDA receptors are heterotetramers of seven genetically encoded, differentially expressed subunits including NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The early expression of this gene in development suggests a role in brain development, circuit formation, synaptic plasticity, and cellular migration and differentiation. Naturally occurring mutations within this gene are associated with neurodevelopmental disorders including autism spectrum disorder, attention deficit hyperactivity disorder, epilepsy, and schizophrenia.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  POU6F1_01 ,  STAT4_01 ,  GATA1_03 ,  GATA1_01 ,  STAT1_02 ,  TTANTCA_UNKNOWN ,  ATF6_01 ,  FOXJ2_02 ,  RSRFC4_01 ,  SYATTGTG_UNKNOWN ,  YTATTTTNR_MEF2_02 ,  ZF5_01 ,  STAT6_02 ,  AAANWWTGC_UNKNOWN ,  PEA3_Q6 ,  RSRFC4_Q2 ,  YATTNATC_UNKNOWN ,  SRY_01 ,  AMEF2_Q6 ,  STAT1_03 ,  CTAWWWATA_RSRFC4_Q2 ,  GCCATNTTG_YY1_Q6 ,  MYCMAX_B ,  GATA1_04 ,  WHN_B ,  HEB_Q6 ,  GGGAGGRR_MAZ_Q6 ,  MEF2_02 ,  STAT_Q6 ,  TATAAA_TATA_01 ,  DBP_Q6 ,  TCCCRNNRTGC_UNKNOWN ,  CEBP_01 ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  AP4_Q6 ,  YY1_01 ,  PXR_Q2 ,  SP3_Q3 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  PITX2_Q2 ,  LMO2COM_02 ,  E4F1_Q6 ,  AHR_Q5 ,  MGGAAGTG_GABP_B ,  EVI1_06 ,  HMEF2_Q6 ,  NRF1_Q6 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  AAAYRNCTG_UNKNOWN ,  AFP1_Q6 ,  IK2_01 ,  MSX1_01 ,  STAT5A_04 ,  GATA1_05 ,  MEF2_03 ,  IK3_01 ,  RGAGGAARY_PU1_Q6 ,  TATA_01 ,  IK1_01 ,  TGCTTTG_MIR330 ,  CTTTGT_LEF1_Q2 ,  TBP_01 ,  CAGCTG_AP4_Q5 ,  PAX4_03 ,  CRX_Q4 ,  CEBPGAMMA_Q6 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

12p13.1

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