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QuickView for NRF2 (gene)


Gene Symbol:
Nfe2l2 Mus musculus Mus musculus
Full name:
nuclear factor, erythroid derived 2, like 2
Synonyms:
Nrf2, nuclear factor erythroid 2-related factor 2, NF-E2-related factor 2, NFE2-related factor 2
Genomic Location:
Chr 2: 75513576-75542698
Description:
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production...
Orthologs:
Homo sapiens Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Canis lupus familiaris Bos taurus Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_010902
NR_132727
Protein Names
Q60795
Q3UQK0



GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | enhancer binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | protein domain specific binding | enhancer sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | protein heterodimerization activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | protein dimerization activity | RNA polymerase II regulatory region sequence-specific DNA binding | RNA polymerase II distal enhancer sequence-specific DNA binding | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | transcription cofactor binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | response to extracellular stimulus | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | regulation of hydrogen peroxide-induced cell death | cellular response to glucose starvation | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | response to nutrient levels | negative regulation of immune system process | negative regulation of hematopoietic progenitor cell differentiation | response to endoplasmic reticulum stress | response to cytokine | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of neurogenesis | proteolysis | regulation of cell development | regulation of localization | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | regulation of immune system process | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of hematopoietic stem cell differentiation | cellular response to tumor necrosis factor | regulation of cardiac muscle cell apoptotic process | cell differentiation | defense response | nervous system development | cellular response to extracellular stimulus | response to drug | regulation of hematopoietic progenitor cell differentiation | neurogenesis | positive regulation of cellular component movement | generation of neurons | response to antibiotic | PERK-mediated unfolded protein response | positive regulation of cellular biosynthetic process | cellular process | organic substance catabolic process | regulation of glucose import | regulation of cell motility | regulation of removal of superoxide radicals | cellular homeostasis | toxin metabolic process | proteolysis involved in cellular protein catabolic process | negative regulation of smooth muscle cell migration | negative regulation of signaling | positive regulation of blood coagulation | positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress | positive regulation of reactive oxygen species metabolic process | regulation of embryonic development | endoplasmic reticulum unfolded protein response | negative regulation of apoptotic process | response to hypoxia | cellular response to starvation | mycotoxin metabolic process | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | regulation of neuron projection development | response to inorganic substance | regulation of cell differentiation | negative regulation of apoptotic signaling pathway | response to hydrogen peroxide | negative regulation of cell motility | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | RNA biosynthetic process | negative regulation of oxidative stress-induced cell death | cellular response to unfolded protein | response to topologically incorrect protein | cellular aromatic compound metabolic process | negative regulation of response to drug | cellular response to topologically incorrect protein | positive regulation of epithelial cell migration | regulation of vasculature development | response to stimulus | negative regulation of epithelial cell apoptotic process | transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding | cellular response to hypoxia | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | cell redox homeostasis | cellular nitrogen compound biosynthetic process | regulation of response to drug | aflatoxin metabolic process | response to laminar fluid shear stress | positive regulation of glucose import | response to starvation | regulation of smooth muscle cell migration | cellular protein catabolic process | cellular nitrogen compound metabolic process | cellular response to toxic substance | proteasomal protein catabolic process | positive regulation of blood vessel endothelial cell migration | positive regulation of RNA biosynthetic process | regulation of wound healing | negative regulation of hemopoiesis | protein modification process | cellular biosynthetic process | macromolecule modification | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | regulation of superoxide metabolic process | system development | cellular response to nutrient levels | response to oxygen levels | positive regulation of response to wounding | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of neuron projection development | cellular response to antibiotic | multicellular organism development | negative regulation of striated muscle cell apoptotic process | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | cellular response to oxidative stress | ER-nucleus signaling pathway | regulation of intrinsic apoptotic signaling pathway | regulation of hematopoietic stem cell differentiation | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | protein catabolic process | negative regulation of hydrogen peroxide-induced cell death | positive regulation of cellular metabolic process | regulation of blood coagulation | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of cell migration | positive regulation of cell projection organization | cellular response to fluid shear stress | regulation of cellular component movement | regulation of transcription by RNA polymerase II | mycotoxin catabolic process | regulation of endothelial cell apoptotic process | response to oxidative stress | positive regulation of cell differentiation | regulation of endothelial cell migration | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | positive regulation of cell migration | negative regulation of cardiac muscle cell apoptotic process | cellular response to cytokine stimulus | positive regulation of glucose transmembrane transport | biosynthetic process | negative regulation of vascular associated smooth muscle cell migration | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | response to toxic substance | regulation of apoptotic signaling pathway | regulation of epithelial cell apoptotic process | cellular response to drug | regulation of cellular response to drug | regulation of muscle cell apoptotic process | cell communication | regulation of cellular metabolic process | inflammatory response | proteasomal ubiquitin-independent protein catabolic process | homeostatic process | regulation of locomotion | regulation of RNA metabolic process | regulation of stem cell differentiation | positive regulation of transport | proteasome-mediated ubiquitin-dependent protein catabolic process | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | DNA-binding transcription factor activity | response to organic substance | protein ubiquitination | regulation of hemopoiesis | regulation of response to reactive oxygen species | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | anatomical structure development | positive regulation of neurogenesis | metabolic process | positive regulation of cell development | negative regulation of response to oxidative stress | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of coagulation | cellular response to hydrogen peroxide | negative regulation of muscle cell apoptotic process | nucleobase-containing compound metabolic process | cellular response to reactive oxygen species | organic substance metabolic process | negative regulation of intrinsic apoptotic signaling pathway | regulation of glucose transmembrane transport | response to reactive oxygen species | gene expression | negative regulation of cellular component movement | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | protein modification by small protein conjugation or removal | negative regulation of stem cell differentiation | positive regulation of wound healing | transcription, DNA-templated | positive regulation of endothelial cell migration | ubiquitin-dependent protein catabolic process | regulation of epithelial cell migration | organonitrogen compound catabolic process | response to fluid shear stress | regulation of response to wounding | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of signal transduction | signaling | regulation of transcription, DNA-templated | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | response to unfolded protein | cellular macromolecule biosynthetic process | regulation of nervous system development | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | developmental process | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | detoxification | positive regulation of nucleic acid-templated transcription | positive regulation of glutathione biosynthetic process | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | cellular response to laminar fluid shear stress | aflatoxin catabolic process | positive regulation of metabolic process | positive regulation of neuron differentiation | regulation of cell projection organization | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | modification-dependent protein catabolic process | negative regulation of cell death | negative regulation of locomotion | positive regulation of angiogenesis | negative regulation of cell differentiation | regulation of cellular component organization | signal transduction | regulation of signaling | negative regulation of endothelial cell apoptotic process | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | microtubule organizing center | cell | nuclear lumen | cytoplasm | intracellular organelle | centrosome | Golgi apparatus | protein-containing complex | endomembrane system | protein-DNA complex | nucleoplasm | plasma membrane | chromatin | microtubule cytoskeleton | membrane-bounded organelle | nucleus | organelle | cell periphery | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | membrane