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QuickView for NSD1;jsessionid=5DEFB28AA6506D852E208E7810A68700 (gene)


Gene Symbol:
NSD1 Homo sapiens Homo sapiens
Full name:
nuclear receptor binding SET domain protein 1
Synonyms:
ARA267, KMT3B, SOTOS, SOTOS1, STO, histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, H3-K36-HMTase, H4-K20-HMTase, NR-binding SET domain-containing protein, androgen receptor coactivator 267 kDa protein, androgen receptor-associated coregulator 267, androgen receptor-associated protein of 267 kDa, lysine N-methyltransferase 3B, nuclear receptor-binding SET domain-containing protein 1
Genomic Location:
Chr 5: 176493532-176655369
Description:
This gene encodes a protein containing a SET domain, 2 LXXLL motifs, 3 nuclear translocation signals (NLSs), 4 plant homeodomain (PHD) finger regions, and a proline-rich region. The encoded protein enhances androgen receptor (AR) transactivation, and this enhancement can be increased further in the presence of other androgen receptor associated cor...
Orthologs:
Mus musculus Rattus norvegicus Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q35.3





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | retinoic acid receptor binding | cation binding | hormone receptor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | S-adenosylmethionine-dependent methyltransferase activity | estrogen receptor binding | signaling receptor binding | thyroid hormone receptor binding | catalytic activity | chromatin binding | RNA polymerase II regulatory region DNA binding | androgen receptor binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | nuclear hormone receptor binding | histone methyltransferase activity | ion binding | organic cyclic compound binding | retinoid X receptor binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcription factor binding | N-methyltransferase activity | RNA polymerase II regulatory region sequence-specific DNA binding | transferase activity | transition metal ion binding | histone methyltransferase activity (H3-K36 specific) | histone methyltransferase activity (H4-K20 specific) | protein-lysine N-methyltransferase activity | steroid hormone receptor binding | methyltransferase activity | transcription coregulator activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | positive regulation of macromolecule biosynthetic process | peptidyl-amino acid modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | histone-lysine N-methyltransferase activity | lysine N-methyltransferase activity | protein methyltransferase activity | regulation of organelle organization | positive regulation of cellular biosynthetic process | cellular process | chromatin organization | negative regulation of nucleic acid-templated transcription | regulation of histone modification | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | regulation of binding | regulation of cellular process | regulation of metabolic process | S-adenosylmethionine-dependent methyltransferase activity | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | regulation of histone methylation | cellular nitrogen compound biosynthetic process | regulation of transcription regulatory region DNA binding | cellular nitrogen compound metabolic process | regulation of DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | protein modification process | cellular biosynthetic process | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | histone methylation | regulation of phosphorylation | regulation of gene expression | methylation | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | transcription corepressor activity | regulation of transcription by RNA polymerase II | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | histone methyltransferase activity | regulation of histone H3-K36 methylation | regulation of cellular metabolic process | regulation of protein metabolic process | histone H4-K20 methylation | regulation of protein phosphorylation | regulation of RNA metabolic process | histone H3-K36 methylation | protein metabolic process | peptidyl-lysine methylation | N-methyltransferase activity | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | peptidyl-lysine modification | nucleobase-containing compound metabolic process | organic substance metabolic process | histone lysine methylation | negative regulation of biosynthetic process | negative regulation of gene expression | gene expression | regulation of phosphate metabolic process | histone methyltransferase activity (H3-K36 specific) | regulation of chromosome organization | transcription, DNA-templated | histone methyltransferase activity (H4-K20 specific) | regulation of peptidyl-serine phosphorylation | covalent chromatin modification | regulation of transcription, DNA-templated | protein-lysine N-methyltransferase activity | cellular protein metabolic process | cellular macromolecule biosynthetic process | protein methylation | methyltransferase activity | regulation of RNA polymerase II regulatory region sequence-specific DNA binding | organelle organization | cellular protein modification process | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | cellular metabolic process | regulation of cellular component organization | positive regulation of gene expression | macromolecule metabolic process | regulation of chromatin organization | regulation of phosphorus metabolic process

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | cell | nuclear lumen | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular