QuickView for NT-3 (gene)

Gene Symbol:

NTF3 Homo sapiens

Full name:

neurotrophin 3

Synonyms:

HDNF, NGF-2, NGF2, NT-3, NT3, neurotrophin-3, nerve growth factor 2, neurotrophic factor

Genomic Location:

Chr 12: 5411541-5474726

Description:

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the e...

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The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  POU6F1_01 ,  RTAAACA_FREAC2_01 ,  ATAAGCT_MIR21 ,  FREAC7_01 ,  TAL1ALPHAE47_01 ,  AREB6_02 ,  FOX_Q2 ,  HFH1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  GATAAGR_GATA_C ,  CTTTGA_LEF1_Q2 ,  TGACCTY_ERR1_Q2 ,  TATAAA_TATA_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  RRAGTTGT_UNKNOWN ,  FOXJ2_01 ,  HFH8_01 ,  SOX5_01 ,  RORA1_01 ,  TTGTTT_FOXO4_01 ,  ATATGCA_MIR448 ,  CAGTATT_MIR200B_MIR200C_MIR429 ,  TEF_Q6 ,  TBP_01 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  BRN2_01 ,  ERR1_Q2 ,  HNF1_Q6 ,  TGACCTTG_SF1_Q6 ,  HNF6_Q6 ,  TATTATA_MIR374 ,  CCTNTMAGA_UNKNOWN ,  HOX13_01 ,  SF1_Q6 ,  ATGTAGC_MIR221_MIR222 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-200b ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

12p13.31

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