QuickView for NTRK1 (gene)

Gene Symbol:

NTRK1 Homo sapiens

Full name:

neurotrophic receptor tyrosine kinase 1

Synonyms:

MTC, TRK, TRK1, TRKA, Trk-A, p140-TrkA, high affinity nerve growth factor receptor, Oncogene TRK, TRK1-transforming tyrosine kinase protein, gp140trk, neurotrophic tyrosine kinase, receptor, type 1, tropomyosin-related kinase A, tyrosine kinase receptor A

Genomic Location:

Chr 1: 155052166-155118266

Description:

This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this...

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This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  P53_DECAMER_Q2 ,  EFC_Q6 ,  VDR_Q3 ,  NKX22_01 ,  CDPCR3HD_01 ,  CDPCR1_01 ,  GGGCGGR_SP1_Q6 ,  GCM_Q2 ,  PTF1BETA_Q6 ,  HLF_01 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  CEBP_C ,  PAX_Q6 ,  E2F_Q2 ,  TGACAGNY_MEIS1_01 ,  YNGTTNNNATT_UNKNOWN

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Cytogenetic Map:

1q23.1

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