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QuickView for NUDT15;jsessionid=76135497AA9A1C2961CA7E3232018A32 (gene)


Gene Symbol:
NUDT15 Homo sapiens Homo sapiens
Full name:
nudix hydrolase 15
Synonyms:
MTH2, NUDT15D, nucleotide triphosphate diphosphatase NUDT15, 8-oxo-dGTPase NUDT15, mutT homolog 2, nucleoside diphosphate-linked to another moiety X hydrolase 15, nudix (nucleoside diphosphate linked moiety X)-type motif 15, probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15, probable 8-oxo-dGTP diphosphatase NUDT15
Genomic Location:
Chr 13: 47509704-47519283
Description:
This gene encodes an enzyme that belongs to the Nudix hydrolase superfamily. Members of this superfamily catalyze the hydrolysis of nucleoside diphosphates, including substrates like 8-oxo-dGTP, which are a result of oxidative damage, and can induce base mispairing during DNA replication, causing transversions. The encoded enzyme is a negative regu...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Bos taurus Pan troglodytes Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 13
13q14.2





GO Molecular Function

8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | cation binding | 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | NADH pyrophosphatase activity | hydrolase activity | pyrophosphatase activity | catalytic activity | ion binding | nucleoside-triphosphate diphosphatase activity | protein binding | nucleoside-diphosphatase activity | hydrolase activity, acting on acid anhydrides | metal ion binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | nucleotide diphosphatase activity

GO Biological Process

response to extracellular stimulus | nucleoside phosphate catabolic process | deoxyribonucleoside triphosphate metabolic process | cellular response to extracellular stimulus | response to drug | organophosphate catabolic process | cellular process | organic substance catabolic process | nucleotide metabolic process | carbohydrate derivative catabolic process | dGTP catabolic process | regulation of proteolysis | nucleoside triphosphate metabolic process | regulation of cellular process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | purine nucleotide metabolic process | regulation of cellular protein catabolic process | response to stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | deoxyribose phosphate catabolic process | cellular biosynthetic process | nucleobase-containing compound catabolic process | drug catabolic process | nitrogen compound metabolic process | purine deoxyribonucleoside triphosphate catabolic process | phosphorus metabolic process | cellular response to stress | cell cycle | organophosphate metabolic process | deoxyribonucleotide metabolic process | nucleobase-containing small molecule catabolic process | regulation of nitrogen compound metabolic process | small molecule metabolic process | exogenous drug catabolic process | nucleobase-containing small molecule metabolic process | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | nucleotide catabolic process | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | aromatic compound catabolic process | drug metabolic process | deoxyribonucleoside triphosphate catabolic process | DNA metabolic process | mitotic cell cycle | metabolic process | regulation of protein catabolic process | regulation of proteasomal protein catabolic process | dGTP metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | DNA protection | organonitrogen compound catabolic process | nucleoside triphosphate catabolic process | carbohydrate derivative metabolic process | deoxyribonucleotide catabolic process | heterocycle metabolic process | cellular metabolic process | purine nucleotide catabolic process | macromolecule metabolic process

GO Cellular Component

cell | cytoplasm | cytosol | intracellular